在药物诱导的睡眠内镜上,阻塞性模式中的性别差异.
Tiffany Husman1, Tania Benjamin1, Megan L Durr1
1Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA.
概括
患有阻塞性睡眠呼吸暂停 (OSA) 的女性在药物诱导睡眠内镜 (DISE) 期间表现出较少的完全口腔内崩. 需要进一步的研究来了解OSA生理学的基于性别的差异.
科学领域:
- 睡眠医学 睡眠医学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 呼吸系统医学 呼吸系统医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的疾病,影响着全球数以百万计的人.
- 药物诱导睡眠内镜 (DISE) 是OSA的一个关键诊断工具.
- 了解OSA病理生理学的基于性别的差异对于定制治疗至关重要.
研究的目的:
- 调查和描述在DISE期间观察到的OSA男性和女性患者之间崩模式的差异.
- 为了确定特定的解剖学或生理学因素,有助于这些基于性别的变化在气道崩.
主要方法:
- 从2020年到2023年接受DISE的成年患者的回顾性队列分析.
- 包括117名患者 (30%为女性) 具有不同程度的OSA严重程度.
- 单变量和多变量分析以比较性别之间的崩模式,控制BMI和呼吸暂停-呼吸暂停指数 (AHI).
主要成果:
- 性别之间没有 palatine或语言桃体大小的显著差异.
- 女性表现出完全口腔大侧壁倒塌的比率明显较低 (25.7%对比男性的51.2%,P=.008).
- 男性性别是完全口腔大塌的独立预测因素 (OR 2.55),而更高的BMI预测了任何口腔大塌.
结论:
- 较少比例的女性在OSA中经历了完全的耳鼻侧壁崩,独立于BMI和AHI.
- 这些发现突出了OSA机制中潜在的性别特异性差异.
- 需要进一步的研究来阐明男性和女性之间OSA的潜在生理变异.
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