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在宫检查结果呈阳性后,对持续性人类乳头瘤病毒的监测的替代方案:系统性审查和元分析

A E McGee¹, S Hawco¹, S Bhattacharya¹

¹Aberdeen Centre for Women's Health Research, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, Scotland, UK.

European journal of obstetrics, gynecology, and reproductive biology

|October 6, 2024

概括

世卫组织的新指导方针意味着越来越多的女性知道他们患有高风险的人类乳头瘤病毒 (HR-HPV). 本综述确定了持续的HR-HPV和低度宫内皮瘤 (CIN) 的治疗方法,为监测提供了替代方案.

科学领域:

妇科妇科医生妇科
在瘤学瘤学.
病毒学病毒学

背景情况:

2021年世卫组织的指导方针将宫查转变为初级高风险人类乳头瘤病毒 (HR-HPV) 检测.
这种转变增加了对HR-HPV的认识,导致了潜在的焦虑和对超越监视的积极治疗的渴望.
目前对持续性HR-HPV和低度宫内皮质瘤 (CIN ≤1) 的治疗主要涉及"观察和等待"的方法.

研究的目的:

确定持久HR-HPV和/或CIN ≤1.1的妇女的潜在治疗选择.
评估这些治疗的临床有效性,重点关注HR-HPV清除率和CIN回归率.

主要方法:

在主要数据库 (MEDLINE,PubMed,EMBASE,Web of Science,Cochrane Library) 中进行了系统的文献搜索.
包括的研究包括队列研究和随机对照试验 (RCT).
使用ROBINS-I和ROB-2工具评估了研究质量.

主要成果:

包括12项研究 (4队列,8项RCT),检查口服药物,局部治疗,疫苗接种和非手术设备.
分析表明,阴道凝,光动力疗法和某些口服药物可能会促进较早的HR-HPV清除和CIN回归,而不是自然清除.
干预包括六种口服药物,2种局部药物,1种疫苗和3种非手术设备治疗.

结论:

本综述提供了针对持续性HR-HPV和低级CIN的治疗干预措施的证据.
调查结果可以为与HR-HPV阳性女性的临床讨论提供关于监测治疗替代方案的信息.

关键词:

宫部查是指宫部的查.人类乳头瘤病毒的人类乳头瘤病毒持续的人类乳头瘤病毒感染.监督监督监督监督监督监督监督监督监督监督监督监督治疗方法治疗方法

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