细胞巨病毒胎儿病变中的骨损伤:神经声学研究
Karina Krajden Haratz1,2, Gustavo Malinger3,4, Hadas Miremberg3,4
1Division of Ultrasound in ObGyn at Lis Maternity and Women's Hospital, Tel Aviv Medical Center, Tel Aviv, Israel, ninakrajden@gmail.com.
Fetal diagnosis and therapy
|October 6, 2024
概括
细胞巨乳病毒 (CMV) 感染可以导致胎儿的体 (CC) 大脑异常,即使是晚期感染. 这些CC损伤与较差的结果和增加的神经发育风险有关.
科学领域:
- 胎儿医学 胎儿医学
- 神经成像是一种神经成像.
- 传染性疾病 传染性疾病
背景情况:
- 由于先天性感染,胎儿大脑形症中很少记录体 (CC) 异常.
- 细胞巨乳病毒 (CMV) 感染是先天胎儿大脑异常的重要原因之一.
- 在CMV胎儿病症中,骨损伤的特定模式和频率需要进一步调查.
研究的目的:
- 确定被诊断为细胞巨核病毒 (CMV) 胎儿病变的胎儿中体 (CC) 损伤的发生率和特征.
- 分析CMV感染中CC异常和其他中枢神经系统 (CNS) 发现之间的关联.
- 了解CC参与对产前诊断和预后的影响.
主要方法:
- 在单个中心对已确认CMV-PCR的胎儿进行回顾性分析.
- 详细的神经声学使用高频探测器,并在可行的情况下通过阴道 (TV) 路线.
- 胎儿大脑生物测量,包括体 (CC) 长度和CC/OFD比率,其异常定义为低于第五个百分点或形态缺陷.
主要成果:
- 在72名患有CMV感染的胎儿中,有34.7%的胎儿发现了体 (CC) 异常,这从来不是一个孤立的发现.
- 常见的中枢神经系统异常包括周周结膜性超高原性 (PVHE) (55.5%) 和化 (52%).
- 在19例病例中观察到显著的CC异常,包括短CC,缺席CC和带有化的CC.
结论:
- 大脑体 (CC) 在约三分之一的胎儿中受到细胞巨核病毒 (CMV) 感染的影响,即使是在晚期或二次感染的情况下.
- 在CMV胎儿病变中CC参与的产前模式与产后发现不同,并且似乎是不可逆转的.
- 在CMV胎儿病变中,骨损伤与更糟糕的预后和神经发育障碍的风险增加有关.
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