在SARS-CoV-2感染后康复的患者的肠道炎症和透性
Antonella Gallo1, Celeste Ambra Murace2, Michela Maria Corbo3
1Department of Geriatrics and Orthopedics, Fondazione Policlinico Universitario "A. Gemelli," IRCCS, Rome, Italy.
Digestive diseases (Basel, Switzerland)
|October 6, 2024
概括
长期COVID的胃肠道症状与局部炎症没有很强的联系. 对肠-大脑相互作用的感染后疾病的进一步研究对于更好的患者管理至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 长期COVID的胃肠道 (GI) 问题与感染后的肠-大脑相互作用 (PI-DGBIs) 障碍有关.
- 在SARS-CoV-2感染后的长期胃肠道连续病变背后的机制尚不清楚.
- 这项研究调查了康复个体的肠道炎症和透性.
研究的目的:
- 为了评估SARS-CoV-2幸存者的肠道炎症和透性.
- 为了将这些因素与长期的胃肠道疾病相关联.
- 用罗马四号标准评估PI-DGBIs的存在.
主要方法:
- 八十六名康复的SARS-CoV-2受试者在感染后6个月被评估.
- 便中的calprotectin (FC) 测量了肠道炎症;血清和便中的zonulin测量了肠道透性.
- 罗马IV,HADS和GIQLI问卷评估了胃肠道症状,焦虑/抑郁和生活质量.
主要成果:
- 43%的受试者报告了长期的胃肠道症状;33个符合PI-DGBI的罗马四号标准.
- 在无症状受试者中观察到更高的FC水平 (p=0.03),但仍然接近正常.
- 没有发现肠道透性的显著差异;GIQLI显示了肠道和生活质量之间的反向相关性 (p=0.009).
结论:
- 长期COVID的胃肠道疾病可能不是源于局部炎症过程.
- 了解COVID后的PI-DGBIs是非常重要的,因为它们对健康和社会产生了重大影响.
- 鼓励进一步的研究,以改善这些新出现的条件的管理.
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