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对比分析揭示了小鼠和野马的丸下降和阴囊发育中的保存和修改的步骤

Yoshio Wakamatsu¹, Yawara Takeda², Koji Tamura²

¹Department of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Sendai, Japan.

Cells, tissues, organs

|October 6, 2024

概括

丸下降机制在有袋动物和胎盘哺乳动物中演变不同. 尤瑟里亚的阴囊发育涉及到新的调节途径,这种调节途径在像鱼这样的转基因动物中没有见过.

科学领域:

进化生物学是进化的生物学.
比较解剖学的比较解剖学.
发育生物学是发展生物学.

背景情况:

哺乳动物的丸下降到阴囊,但其相对于阴茎的位置在有袋动物 (头骨) 和胎盘哺乳动物 (尾骨) 之间有所不同.
之前的研究表明丸下降机制的共同祖先,促使人们对阴囊定位的独立进化进行调查.

研究的目的:

为了比较丸下降和阴囊发育的组织学和分子过程,在一个metatherian () 和一个eutherian (老鼠).
为了阐明阴囊丸发育的进化路径.

主要方法:

丸下降和阴囊发育的组织学和分子比较.
采用灰色短尾 (Monodelphis domestica) 作为甲状动物模型和小鼠作为eutherian模型.
采用细胞标记分析和Gsc1.1的动态表达研究.

主要成果:

体下降的横腹部阶段在子和老鼠之间是相似的.
阴囊阶段因阴囊的不同位置而不同,在小鼠发育过程中观察到广泛的细胞/组织重组.
在小鼠的阴囊发育中检测到Gsc1表达,但在正在发育的鱼生殖器和阴囊中没有.

结论:

阴囊发育和丸下降的阴囊阶段可能涉及在eutherian进化过程中招募新的调节途径.
建议分泌体形态和功能在转化体和eutherians之间有不同的进化轨迹.

关键词:

密码主义是什么?密码主义是什么?在 Gsc1 的基础上它们是 marsupial 的类型.阴囊是什么意思阴囊是什么意思 Scrotum 丸下降丸下降

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