在波多黎各的儿童中产前多环芳暴露和神经发育
Savannah M Sturla Irizarry1, Amber L Cathey1, Emily Zimmerman2
1Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA.
Chemosphere
|October 6, 2024
概括
对多环芳 (PAHs) 的产前暴露与神经发育迟缓 (NDD) 的概率总体较低有关. 然而,男性婴儿的NDD几率增加,特别是在精细运动技能方面,这表明性别特异性影响.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 多环芳 (PAH) 是燃烧有机物质的常见环境污染物.
- 暴露于PAH与健康问题有关,但其对神经发育延迟 (NDD) 的影响尚未研究.
研究的目的:
- 调查产前PAH暴露与NDD的可能性之间的关联.
- 探索产前PAH暴露对儿童神经发育的潜在性别特异性影响.
主要方法:
- 在PROTECT队列中的孕妇尿液中测量了7个氧化PAH代谢物.
- 在多个时间点 (12-48个月) 在五个领域使用年龄和阶段问卷评估NDD.
- 采用后勤和混合效应后勤回归模型来分析PAH-NDD关联.
主要成果:
- 较高的产前PAH暴露通常与较低的NDD概率有关.
- 一个显著的性别差异出现了:男性儿童在增加PAH暴露时表现出更高的NDD几率.
- 具体来说,1-hydroxypyrene暴露与男性婴儿的精细运动延迟有显著的关联.
结论:
- 产前PAH暴露可能会根据性别对神经发育产生不同的影响.
- 研究结果表明,PAHs可能会对男性儿童的运动功能发展产生负面影响.
- 需要进一步的研究来阐明PAH神经发育影响背后的性别特异性生物机制.
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