将损伤相关的人类侵略映射到一个共同的大脑网络中
Shaoling Peng1, Frederic L W V J Schaper2, Shira Cohen-Zimerman3
1Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Biological psychiatry
|October 6, 2024
概括
与侵略相关的大脑病变形成了一个特定的网络,主要与右前额叶皮层相连. 这一发现确定了治疗侵略性和相关神经精神病症状的潜在目标.
科学领域:
- 神经科学是一个神经科学.
- 神经生物学 神经生物学 神经生物学
- 精神病学是一个精神病学.
背景情况:
- 侵略性对社会构成重大负担,在神经精神疾病中很常见.
- 攻击的潜在神经机制仍然不太清楚,限制了有效的治疗选择.
研究的目的:
- 使用病变网络映射识别与侵略相关的神经网络.
- 调查这种网络损伤与与侵略有关的症状之间的关系.
- 探索这个神经调节网络的治疗潜力.
主要方法:
- 利用了来自182名越南战争退伍军人头部透伤害的数据的损伤网络映射.
- 使用哈佛损伤库 (N=852) 评估与侵略有关的神经精神病症状的验证结果.
- 对患者的深度大脑刺激数据集 (N=25) 进行了检查,以探索治疗相关性.
主要成果:
- 与侵略相关的病变映射到一个特定的网络,其中心位于右前额叶皮质.
- 这种网络显示出与不同大脑区域的积极和消极功能连接的独特模式.
- 在24种神经精神病症状中,犯罪与侵略网络的对齐是最强的;深度大脑刺激连接与易怒性相关.
结论:
- 与侵略相关的大脑病变定义了一个特定的人类大脑电路.
- 这个电路中的功能连接区域为治疗神经调节提供了潜在的目标.
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