血甘油三水平和循环白细胞之间的潜在因果关系和时间关系
Jing Xian Fang1, Hui Min Zou1, Jian Meng1
1Department of Endocrinology, Shidong Hospital, University of Shanghai for Science and Technology, Shanghai, China.
Journal of lipid research
|October 6, 2024
概括
高水平的甘油三与增加的总数,淋巴细胞和中性粒细胞数量有关. 淋巴细胞计数也因果关系地影响甘油三水平,这表明影响血管健康的双向关系.
科学领域:
- 心血管科学 心血管科学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 循环中的甘油三水平 (TG) 和白细胞计数是血管系统的关键组成部分.
- 它们的相互关系和对动脉样硬化的贡献尚未完全理解.
- 血TG和白细胞计数之间的因果关系需要澄清.
研究的目的:
- 调查血甘油三水平和白细胞计数 (包括亚型) 之间的潜在因果关系.
- 使用纵向数据检查TG水平和白细胞计数之间的时间动态.
主要方法:
- 使用双向门德尔随机化 (MR) 分析.
- 一个交叉滞后面板模型 (CLPM) 使用了13389名成年人的4年数据.
- 使用与TG水平和白细胞计数相关的遗传变异.
主要成果:
- 基因预测的TG水平与白细胞总计数 (TLC),淋巴细胞计数 (LC) 和中性粒细胞计数 (NC) 有积极关联.
- 基因预测TLC,LC和NC与血TG水平积极相关.
- 在MR的相互调整后,只有LC显示出与TG水平的显著关联.
- CLPM表明白细胞对TG水平的时间影响更强,而不是相反.
- 没有发现TG水平与单细胞,基细胞或乙氨基细胞计数之间的关联.
结论:
- 血TG水平与TLC,LC和NC有因果关系.
- 淋巴细胞计数与血TG水平具有显著的积极关联.
- 循环淋巴细胞数量增加可能会在血TG水平增加之前发生,这表明潜在的早期标志物.
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