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基底侧杏仁体输入到核贝调节了线索反应和抑制性回避学习的巩固

Bess Glickman¹, Krista L Wahlstrom², Jason J Radley³

¹Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, United States.

Neurobiology of learning and memory

|October 6, 2024

概括

底侧杏仁体 (BLA) 通过其投影影响记忆巩固. 抑制BLA-核 accumbens外路径特别损害了暗示响应和抑制性回避学习,但不是空间记忆.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
记忆的巩固记忆的巩固

背景情况:

已知底侧杏仁体 (BLA) 通过向各种大脑区域的投射来调节记忆巩固.
在行为和记忆中,BLA与核贝 (NAshell) 之间的相互作用是相关的,但特定的BLA-NAshell路径的作用尚不清楚.

研究的目的:

调查BLA-NAshell途径在巩固不同类型记忆中的直接作用:提示-响应,空间和抑制回避 (IA) 学习.
为了确定这种途径的光遗传学操纵是否会影响记忆保留.

主要方法:

使用了雄性和雌性斯普拉格-道利大鼠.
在不同学习任务的训练后立即使用光遗传技术来操纵BLA和BLA-NAshell路径.
通过使用诸如巴恩斯迷宫之类的行为任务来评估记忆保留率.

主要成果:

训练后BLA本身的光遗传抑制损害了暗示响应的保留.
抑制BLA-NAshell通路特别损害了暗示响应和IA学习的保留.
在抑制或刺激BLA-NAshell路径后,没有观察到对空间学习保留的显著影响.

结论:

基底侧桃体通过其投射到核聚合体外来调节暗示响应和抑制回避记忆巩固.
空间记忆的巩固似乎没有被BLA-NAshell路径调节.
这些发现突显了BLA在不同记忆系统中的特定路径作用.

关键词:

基本侧面的杏仁体这是一个Cued-response反应.阻碍性回避是一种阻碍性回避.记忆记忆记忆记忆记忆原子核是一个的外.视觉遗传学视觉遗传学

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