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通过多omics方法确定TFF3和PVRL2的共同向作为一种有效的癌症免疫抑制策略

Peng Huang¹, Tesfaye Wolde², Vipul Bhardwaj¹

¹Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.

|October 6, 2024

概括

三叶草因子3 (TFF3) 和类似于脊髓灰质炎病毒受体2 (PVRL2) 通过创建免疫抑制瘤微环境来促进癌症. 针对TFF3和PVRL2提供了一个有希望的共同向的瘤治疗策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

瘤微环境 (TME) 在癌症的进展和复发中至关重要.
三叶草因子3 (TFF3) 参与调节TME以促进癌症的进展.

研究的目的:

调查TFF3和免疫抑制TME成分之间的关联.
确定一个可共同准的瘤治疗策略.

主要方法:

生物信息分析以确定TFF3-PVRL2的关联.
对PVRL2抑制剂进行虚拟化合物查.
免疫阻塞以验证蛋白质水平相关性.
siRNA和AMPC (TFF3抑制剂) 进行共抑制评估.

主要成果:

观察到TFF3和PVRL2mRNA和蛋白质水平之间存在正相关性.
TFF3和PVRL2相互作用以建立免疫抑制的TME,促进BRCA,LUAD,PAAD,PRAD和STAD中的癌症进展.
丰富分析提供了对它们的共同功能的见解.
对TFF3和PVRL2的联合向显示出治疗疗效.

结论:

PVRL2是一个有前途的免疫抑制标.
PVRL2显示了与TFF3.3的显著关联.
针对TFF3和PVRL2都是一种关键的共同可针对性的瘤治疗策略.

关键词:

癌症复发癌症复发免疫抑制性TME的使用瘤治疗瘤疗法在PVRL2中使用PVRL2.在TFF3中,TFF3是TFF3.

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