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Somayeh Ghiasi Hafezi¹, Bahareh Behkamal², Mohammad Rashidmayvan³

¹International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

Chemistry and physics of lipids

|October 6, 2024

概括

血红蛋白和血小板计数等全血细胞计数 (CBC) 参数与高的LDL胆固醇有关. 红细胞分布宽度 (RDW) 是女性的一个关键预测因素,而RDW-PLT比率和PLT-HDL比率对男性至关重要.

科学领域:

心血管疾病研究研究
血液学血液学血液学
生物标志物发现发现

背景情况:

升高的低密度脂蛋白胆固醇 (LDL-C) 是心血管疾病 (CVD) 的主要危险因素.
已经观察到完整血清 (CBC) 指数和脂质不良症之间的关联.
了解这些联系可以帮助评估心血管疾病风险.

研究的目的:

为了研究CBC参数和血清LDL水平之间的关系.
为了确定特定的CBC生物标志物预测高的LDL-C.
探索这些关联中的性别特异性差异.

主要方法:

对9704名参与者 (35-65岁) 的前性研究.
对LDL-C水平和CBC指标进行全面查.
使用后勤回归,决策树,随机森林,神经网络和支持矢量机器进行分析.

主要成果:

年龄,血红蛋白 (HGB),血红素 (HCT),血小板计数 (PLT),淋巴细胞 (LYM),PLT-LYM比率 (PLR),PLT-HDL比率 (PHR),HGB-LYM比率 (HLR),红细胞计数 (RBC),中性细胞-HDL比率 (NHR) 和PLT-RBC比率 (PRR) 与LDL水平显著相关 (p<0.05).
红细胞分布宽度 (RDW) 显著预测了女性更高的LDL.
对于男性来说,RPR和PHR是最有影响力的,而RDW对女性来说是关键的.

结论:

性别影响LDL-C的几率,女性的几率更高 (52.9%).
年龄和HCT也增加了LDL-C的几率 (分别为4.1%和5.5%).
RPR和PHR是两个性别的关键预测指标;RDW对女性来说是显著的,特别是对于高的HDL-C水平.

关键词:

心血管疾病 (CVD) 是一种心血管疾病.决策树决策树是一个决策树.低密度脂蛋白 (LDL) 是一种低密度脂蛋白.神经网络的神经网络的神经网络随机的森林随机的森林支持矢量机器的支持矢量机器.

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