相关实验视频

Updated: Jun 13, 2025

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

Published on: December 1, 2023

在sevoflurane诱导的小鼠喘息时,上腺肌的活性

Saki Taiji¹, Takashi Nishino¹, Hisayo Jin¹

¹Department of Anesthesiology, Graduate School of Medicine, Chiba University, Japan.

Respiratory physiology & neurobiology

|October 6, 2024

概括

在小鼠中,sevoflurane的喘息涉及增加的吸入力和下部运动. 甲状腺上部肌肉 (SHMs) 在吸气时激活,在喘气时首选作为上呼吸道扩张肌肉.

科学领域:

麻醉学麻醉学
呼吸系统生理学呼吸系统生理学
神经科学是一个神经科学.

背景情况:

塞沃兰麻醉可以诱导喘气,其特点是增加呼吸力度和下部运动.
上呼吸道扩张器 (UAD) 肌肉,特别是上腺肌肉 (SHM) 在sevoflurane诱导的喘息过程中的作用尚未完全理解.

研究的目的:

为了研究SHM在eupnea和sevoflurane诱导的小鼠气喘期间的活性.
为了比较SHM电肌图活动 (EMG_SH) 与潮体积 (V_T) 在喘气时的变化.

主要方法:

研究了8只自发呼吸的气管直通的小鼠,它们接受了eupnea (1MAC sevoflurane) 和gasping (2MAC sevoflurane) 的治疗.
记录和分析了呼吸模式和EMG_SH活动.

主要成果:

阶段性EMG_SH仅在呼吸和喘息期间观察到.
综合EMG_SH在喘气时显著增加,远远超过V_T.
在SHM激活之前,空气流开始,保持了特有的UAD肌肉EMG轮.
在喘息时观察到有力的,与呼吸相关的下运动,但不是eupnea.

结论:

在sevoflurane引起的喘气时,SHM是首选激活的UAD肌肉.
SHM激活有助于在喘气时下部运动的发展.
了解SHM功能,可以了解麻醉引起的呼吸控制机制.

关键词:

气喘的气喘,是一阵气喘的气息.西沃氨酸是什么?甲状腺上部肌肉甲状腺以上肌肉上呼吸道扩张器肌肉上呼吸道扩张器肌肉

更多相关视频

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

Published on: April 5, 2018

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

相关概念视频

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...