Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Spermatogenesis01:41

Spermatogenesis

102.2K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.2K
Infertility in Males01:23

Infertility in Males

253
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
253

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Association of total sedentary behaviour and television viewing with risk of overweight/obesity, type 2 diabetes and hypertension: A dose-response meta-analysis.

Diabetes, obesity & metabolism·2019
Same author

AAV-ie enables safe and efficient gene transfer to inner ear cells.

Nature communications·2019
Same author

The effect of the overexpression of miR-490 on the biological function of prostate cancer cell PC-3.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2019
Same author

Treatment response and outcome of children with T-cell acute lymphoblastic leukemia expressing the gamma-delta T-cell receptor.

Oncoimmunology·2019
Same author

Hypertension is a modifiable risk factor for osteonecrosis in acute lymphoblastic leukemia.

Blood·2019
Same author

Patients' experiences of coping with multiple chronic conditions: A qualitative descriptive study.

Journal of clinical nursing·2019

相关实验视频

Updated: Jun 11, 2025

Fluorimetric Techniques for the Assessment of Sperm Membranes
08:58

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

13.2K

三甲对人类精子的影响:反应性氧物种的积累和线粒体膜潜在的减少.

Houpeng Wang1, Cheng Cheng2, Jing Ding2

  • 1Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Jiangxi Medical College, Nanchang University, Nanchang 330006, China; School of Public Health, Jiangxi Medical College, Nanchang University, China.

Reproductive toxicology (Elmsford, N.Y.)
|October 6, 2024
PubMed
概括

三甲 (TFP),一种抗精神病药,可能会损害男性生育能力. 高度的TFP通过增加活性氧物种 (ROS) 和降低线粒体膜潜力 (MMP) 来降低精子活力.

关键词:
药物重新定位是药物重新定位.人类精液质量的人类精液质量.在体外 (in vitro) 的情况下.细胞内的度是细胞内度.三甲氨酸是一种三甲氨酸.

更多相关视频

Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa
10:24

Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa

Published on: March 11, 2018

6.2K
Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function
08:32

Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function

Published on: June 23, 2023

1.6K

相关实验视频

Last Updated: Jun 11, 2025

Fluorimetric Techniques for the Assessment of Sperm Membranes
08:58

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

13.2K
Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa
10:24

Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa

Published on: March 11, 2018

6.2K
Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function
08:32

Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function

Published on: June 23, 2023

1.6K

科学领域:

  • 生殖毒理学 生殖毒理学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 抗精神病药物使用与人类精子质量降低有关.
  • 一种常见的抗精神病药物 - - 三甲 (Trifluoperazine,TFP) 正在研究其抗癌性质.
  • 对于TFP对人类精子质量的影响尚不清楚.

研究的目的:

  • 在体外研究TFP对人类精子功能和生理参数的影响.
  • 为了确定TFP在精子上的度依赖性毒性.

主要方法:

  • 人类精子与各种度的TFP (12.5,25,50和100微米) 共同培养.
  • 评估了精子功能和生理参数,包括反应性氧物种 (ROS) 生产,线粒体膜潜力 (MMP),活力,运动性,透能力,电容性和体反应.

主要成果:

  • 50微米和100微米的TFP度增加了ROS和减少了MMP,导致精子活力下降.
  • 25μM TFP抑制了精子的透能力,总运动能力和渐进运动能力.
  • 较低的TFP度 (12.5和25微米) 增加了细胞内 ([Ca2+]i),但没有影响电容或体反应,可能是由于缺少增加的氨酸酸化.

结论:

  • TFP可以诱导男性生殖毒性.
  • 毒性机制包括ROS积累和人类精子中MMP降低.
  • 这些发现凸显了TFP使用对男性生育能力的潜在风险.