通过定量PCR对移植后接受者的新发病BK病毒病的评估
Raza Ullah Asif1, Eijaz Ghani1, Muhammad Ali Rathore1
1Armed Forces Institute of Pathology (AFIP), Pakistan.
Transplant immunology
|October 6, 2024
概括
在移植后12个月内,BK多瘤病毒 (BKPyV) 病毒病影响了16.7%的移植接受者. 中年人和女性患病率较高,病毒载量在第三季度达到峰值.
科学领域:
- 病毒学 病毒学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
背景情况:
- 乙基多瘤病毒 (BKPyV) 感染对器官移植接受者构成重大威胁,通常导致乙基病毒相关性病 (BKVAN) 和移植损失.
- 通过查及时检测及及时减少免疫抑制对于预防BKVAN和保持移植功能至关重要.
- 了解BKPyV在尿液中的泄露 (BK病毒病) 的患病率和危险因素对于管理移植后并发症至关重要.
研究的目的:
- 确定移植后第一年内移植受体BK病毒病的发生频率.
- 调查BK病毒病与接受者的年龄,病毒载量和病毒重新激活的时间之间的关联.
- 为了确定影响BKPyV在这个脆弱的患者群体中脱落的人口因素.
主要方法:
- 在12个月内进行了一项前性队列研究,招募了108名移植接受者.
- 每季度收集尿液样本,并使用DNA提取和实时PCR分析BK病毒症.
- 使用统计分析,包括奇平方测试,来评估变量之间的关联.
主要成果:
- 在接受移植的接受者的16.7%中检测到BK病毒.
- 在女性 (20%) 和男性 (16%),相比之下,观察到更高的患病率,和41-60岁的年龄组显示的最高发病率 (61.1%).
- 在年龄和病毒载量 (p=0.01) 和性别和病毒载量 (p=0.019) 之间发现了显著的关联. 大多数阳性病例的病毒载量低于100万副本/毫升,主要是在移植后的第三季度.
结论:
- 该研究发现,在移植后的最初12个月内,BK病毒病的发病率为16.7%.
- 接受者的年龄,特别是中年,与较高的病毒载荷和较早的活性化相关.
- 在最初的九个月中,BK病毒病发病率逐渐增加,在移植后的第三季度达到顶峰,突出显示了关键的监测窗口.
相关概念视频
01:26Kidney Transplant II: Surgical Procedure
2
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
2
01:28Kidney Transplant I: Introduction
2
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
2
01:16Kidney Transplant III: Nursing Management
3
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
3