活跃狼性炎的尿路生物标志物,这些生物标志物经过了跨队列的独立验证
Sonja Vodehnal1, Chandra Mohan1
1Biomedical Engineering Department, University of Houston, Houston, Texas, USA.
Kidney international
|October 6, 2024
概括
经过验证的尿路生物标志物可以区分活跃的狼性炎 (LN) 和不活跃的疾病. 14种蛋白质生物标志物显示出高的诊断潜力,为LN管理提供了潜在的液体活检.
科学领域:
- 腎病學和免疫學 腎病學和免疫學
- 生物标志物发现发现
- 蛋白质组学是指蛋白质组学.
背景情况:
- 狼性炎 (LN) 缺乏独立验证的生物标志物,以区分活跃疾病与不活跃的系统性红斑狼 (iSLE).
- 现有的生物标志物通常显示LN与健康对照者的升高,但临床实用性需要区分活跃和不活跃的疾病状态.
研究的目的:
- 为了确定有效的尿蛋白生物标志物LN与诊断潜力活跃LN (ALN) 与iSLE.
- 对生物标志物的现有文献进行审查,这些生物标志物在多个队伍中得到独立验证.
主要方法:
- 在PubMed和OVID的系统文献搜索,寻找ALN与iSLE尿路生物标志物的研究.
- 评估了40篇同行评审文章,包括来自3,411名患者的数据.
- 在四项或更多研究中多次报告的生物标志物的识别.
主要成果:
- 确定了32种候选生物标志物,其中14种在研究中被反复验证.
- 关键的生物标志物包括ALCAM,CCL2 (MCP1),CD163,HAVCR1 (KIM-1),HPGDS,ICAM-1,ICAM-2,IGFBP-2,LCN2,NCAM-1,SELE,SELL,TNFSF12,以及VCAM-1. 这些生物标志物都被认为是生物标志物.
- 大多数经过验证的生物标志物显示C统计值为0.80或更高,用于区分ALN与iSLE.
结论:
- 可复制性升高的尿蛋白显示为ALN的液体活检具有前途.
- 这些生物标志物是LN诊断,监测,预测和预后应用的潜在候选者.
- 蛋白质组学的进步可能会完善对LN尿路生物标志物的理解和应用.
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