长期COVID综合征中硫热水吸入的影响:以SPA为中心的,双盲的,随机的病例控制试点研究
Serena Crucianelli1, Alessia Mariano2, Federica Valeriani3
1School of Thermal Medicine, Department of Clinical, Internal Medicine, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
硫热水吸入改善了长期COVID症状并减少了炎症. 这项研究发现了鼻子微生物组的显著变化以及患者的客观/主观改善.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 长期COVID综合征表现出多样化的症状,需要非医院治疗策略.
- 长期COVID的社会和经济影响强调需要创新的治疗方法.
- 这项研究探讨了硫热水 (STW) 吸入作为长期COVID的潜在干预措施.
研究的目的:
- 评估硫热水 (STW) 吸入与无菌蒸水 (SDW) 相比在治疗长期COVID症状中的有效性.
- 评估STW吸入对长期COVID患者炎症标志物和鼻腔微生物组合的影响.
- 调查STW治疗后肺功能变化和患者报告的结果.
主要方法:
- 一个双盲,随机对照试验,涉及30名长期COVID门诊患者 (年龄18-75岁).
- 参与者连续12天接受STW或SDW吸入.
- 评估包括症状评分 (6MWT,Borg,SGRQ),血清炎症标志物,鼻微生物组分析和肺功能测试 (PFT) 在基线 (T0),治疗后 (T1) 和3个月的随访 (T2).
主要成果:
- 在STW组T1和T2观察到症状得分 (6MWT,Borg,SGRQ) 的显著改善.
- 血清细胞因子水平和其他炎症生物标志物的统计学显著降低.
- 特定的PFT参数仅在STW组中得到改善,与鼻菌群组成的显著数量和质量转变一起.
结论:
- 硫热水吸入为长期COVID患者提供客观和主观的好处.
- 通过性传播感染的治疗导致炎症标志物和呼吸障碍得分显著减少.
- 鼻微生物群的定量和质量变化与STW干预有关.
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