用于持续的眼部输送,开发带有皮亚林的聚乳酸微球:体外/活体评估
Yanqiu Long1, Jie Hu1, Yan Liu1
1Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
概括
新型微球可以有效地输送皮亚林,用于糖尿病视网膜病变的治疗. 静脉内注射延长药物在眼睛组织中的半衰期,提供持续释放和潜在的治疗益处.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 生物材料科学 生物材料科学
背景情况:
- 糖尿病视网膜病变是成年人失明的主要原因.
- 普埃拉林在治疗糖尿病视网膜病变方面表现有前途.
- 需要有效的眼部药物输送系统.
研究的目的:
- 设计和评价用于眼部施用的聚氨酸 (乳酸) 持续释放微球.
- 评估这些新型微球的体外和体内特性.
- 确定这些微球在治疗糖尿病视网膜病变方面的潜力.
主要方法:
- 使用Box-Behnken响应表面方法准备和优化了带有puerarin的多分子乳酸) 微球.
- 试验室表征包括封装效率,药物加载,分散,安全性和药物释放动力学 (零顺序).
- 在体内研究涉及眼部组织分布 (视网膜,胸膜),比较微球,溶液和静脉注射组.
主要成果:
- 优化的微球实现了35.71%的封装效率和3.85%的药物加载.
- 微球在实验室中显示出良好的分散性,高安全性和持续释放性,遵循零阶动力学.
- 与其他组相比,微球的静脉内注射显著增加了视网膜和胆膜中的Cmax和AUC0-∞.
结论:
- 装有puerarin的微球适用于眼部药物输送,提供持续释放.
- 这些微球体的静脉内注射延长了皮亚林在眼睛组织中的半衰期.
- 这种新型配方对糖尿病视网膜病变的临床治疗具有重大潜力.
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