胆囊癌的环境风险因素:广泛的系统审查和元分析
Daniele Piovani1, Georgios K Nikolopoulos2, Alessio Aghemo3
1Department of Biomedical Sciences, Humanitas University, Milan, Italy; IRCCS Humanitas Research Hospital, Milan, Italy.
概括
胆囊癌 (GBC) 风险因肥胖,胆道感染和高平价而显著增加. 高等教育水平与GBC风险降低有关. 需要进一步的研究来证实这些发现并制定预防策略.
科学领域:
- 胃肠病学和肝病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 胆结石是胆囊癌 (GBC) 的已知危险因素,这是一个普遍存在的胆道恶性瘤.
- 其他可修改的环境暴露对GBC风险的影响需要进一步澄清.
研究的目的:
- 进行与胆囊癌相关的环境因素的系统审查和元分析.
- 评估各种暴露与GBC风险相关的证据的可信度.
主要方法:
- 系统地搜索Medline/PubMed和Embase数据库,直到2023年5月.
- 纵向研究的随机效应元分析,并补充了病例控制研究.
- 使用预先定义的标准评估证据的可信性,包括统计学意义和可靠性.
主要成果:
- 发现与增加GBC风险的强有力的关联是:肥胖,超重,体重指数,腰围,部周长,腰与身高的比例,高平价和胆道感染.
- 高等教育显示,与降低GBC风险的信誉关系中等至高.
- 还有39个重要的关联,包括与烟草,酒精和体育活动相关的关联,可信度较低.
结论:
- 本综合性审查对可修改因素影响GBC风险的证据进行了映射.
- 高质量的前性研究对于验证新兴协会和指导GBC高发病率地区的预防工作至关重要.
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