印度比哈尔州结核病的PLHIV患者的流行病学决定因素和生活质量
Rajat Mishra1, Gopal Vishwas2, Tukaram Kendre1
1Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER) Hajipur, Bihar, India.
结核病 (TB) 联合感染在印度帕特纳的艾滋病毒感染者 (PLHIV) 中很普遍. 晚期艾滋病毒分期和低CD4计数显著增加结核病风险,影响生活质量.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 艾滋病毒/艾滋病研究研究
背景情况:
- 在印度帕特纳,艾滋病毒感染者 (PLHIV) 中结核病 (TB) 的高患病率.
- 艾滋病毒-结核病患者的同时感染评估和生活质量 (QoL) 评估.
研究的目的:
- 在印度帕特纳的PLHIV中确定结核病的流行率.
- 确定导致HIV-TB同时感染的因素.
- 评估同时感染患者的 QoL.
主要方法:
- 在抗逆转录病毒疗法 (ART) 中心进行了长达八个月的横截面研究.
- 通过半结构化问卷和医院记录收集数据.
- 使用SPSS软件进行统计分析.
主要成果:
- 在289名PLHIV患者中,31%患有结核病的同时感染.
- 男性性别,WHO的高级分期,先前的结核病史和机会性感染是重要的预测因素.
- 较高的CD4计数 (>300细胞/毫米3) 降低了同时感染的几率.
- 艾滋病毒-结核病患者报告的QOL明显低于仅艾滋病毒患者.
结论:
- 低CD4+T细胞计数和先进的HIV临床阶段 (世卫组织III/IV阶段) 是结核病共感染的关键风险因素.
- 艾滋病毒-结核病联合感染与患结核病的风险大大增加 (增加四倍).
- 了解这些风险因素对于管理共感染个体至关重要.
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