对胺质子转移和扩散权重成像进行比较分析,以评估膀癌中的ki-67,p53和PD-L1表达
Jing-Lu Li1, Yun Xu1, Yong-Sheng Xiang1
1Department of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China (J-L.L., Y.X., Y-S.X., A-J.S., P-J.W., F.W.); Institute of Medical Imaging Artificial Intelligence, Tongji University School of Medicine, Shanghai 200065, China (J-L.L., Y.X., Y-S.X., A-J.S., P-J.W., F.W.).
Academic radiology
|October 6, 2024
概括
胺基质子转移 (APT) 图像显示与膀癌有显著的相关性.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 生物医学成像技术 生物医学成像技术
背景情况:
- 膀癌 (BC) 的分子亚型对治疗决策至关重要.
- 目前的成像方法在非侵入性评估BC生物标志物方面存在局限性.
- 胺基质子转移 (APT) 成像为分子评估提供了一种新的方法.
研究的目的:
- 评估APT成像在评估膀癌中的Ki-67,p53和PD-L1状态中的有效性.
- 为了比较APT成像与扩散权重成像 (DWI) 的诊断性能.
主要方法:
- 包括APT成像在内的多参数MRI对88名疑似BC患者进行了成像.
- 测量了来自APT的不对称磁化转移比率 (MTRasym) 和来自DWI的明显扩散系数 (ADC).
- 在成像参数和分子标记 (Ki-67,p53,PD-L1) 之间进行了相关性和变异分析.
主要成果:
- MTRasym值与Ki-67,p53和PD-L1表达水平有显著的相关性 (P <0.05).
- 较高的MTRasym值在具有高Ki-67,高p53和阳性PD-L1表达的BC中观察到.
- APT成像显示了对p53 (AUC0.781) 和PD-L1 (AUC0.859) 状态的有希望的诊断性能.
结论:
- APT成像可以显著提高膀癌攻击性的术前评估.
- 在膀癌中,APT成像显示有潜力为向免疫治疗的决策提供信息.
- 与DWI相比,APT成像在评估BC分子状态方面表现优越.
相关概念视频
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