患者的医用大麻剂量轨迹:来自销售数据的证据
Alexandra F Kritikos1, Myfanwy Graham2, Dominic Hodgkin3
1NORC, the University of Chicago, Cambridge, Massachusetts; Leonard D. Schaeffer Center for Health Policy & Economics, University of Southern California, Los Angeles, California.
Clinical therapeutics
|October 6, 2024
概括
医用大麻的剂量在患者之间有很大的差异. 现实世界的数据揭示了delta-9-tetrahydrocannabinol (THC) 和cannabidiol (CBD) 使用的不同轨迹,受医疗条件的影响.
科学领域:
- 药理学 药理学是指药理学的学科.
- 大麻素科学 大麻素科学
- 现实世界的证据 现实世界的证据
背景情况:
- 在全球范围内,医用大麻的使用量正在增加.
- 对于医用大麻剂量的高质量临床试验数据仍然有限.
- 现实世界的数据对于了解患者的剂量模式至关重要.
研究的目的:
- 为了分析纵向医用大麻购买数据.
- 为了确定delta-9-tetrahydrocannabinol (THC) 和cannabidiol (CBD) 的剂量趋势.
- 为了探索各种合格医疗状况的患者的剂量模式.
主要方法:
- 在纽约对16727名患者购买医用大麻 (2016-2019) 的回顾性分析.
- 利用基于组的轨迹建模来识别剂量进展集群.
- 采用了千平方测试来将患者的特征和情况与轨迹组联系起来.
主要成果:
- 确定了THC和CBD的六个不同的剂量轨迹组.
- 大多数患者 (62.6%) 保持稳定的THC剂量 (低或中等).
- 显著的患者子组显示THC剂量波动或增加 (22.0%) 或剂量减少 (15.8%).
- CBD轨迹反映了THC,但通常价值更高 (4-16毫克).
- 慢性疼痛,神经病变和癌症患者喜欢更高的THC剂量;患者喜欢更高的CBD剂量.
结论:
- 医用大麻的剂量在患者群体中显示出显著的异质性.
- 剂量轨迹受到特定医疗状况的影响.
- 现实世界的数据为大麻素治疗管理提供了宝贵的见解.
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