在主观认知衰退和轻度认知障碍中的结构性障碍
Jie Song1,2, Han Yang1,2, Hailang Yan3
1Rehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Gulou District, Nanjing, 210029, China.
Brain imaging and behavior
|October 6, 2024
概括
主观认知衰退 (SCD) 和轻度认知障碍 (MCI) 显示左下叶的共同脑缩. 与MCI相比,SCD在特定的大脑区域呈现出明显的变化.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 主观认知衰退 (SCD) 代表了阿尔茨海默氏病连续性的最早阶段.
- 现有的关于SCD中大脑结构变化的研究不一致,需要进一步调查.
研究的目的:
- 研究和比较SCD,轻度认知障碍 (MCI) 和健康对照 (HC) 个体的结构性大脑变化.
- 识别与认知衰退相关的特定形态和微观结构差异.
主要方法:
- 招募了37名SCD患者,28名MCI患者和42名HC患者.
- 分析了T1和扩散权重的MRI图像,以检测形态和微观结构的差异.
- 利用支持矢量机 (SVM) 基于MRI特征进行分类分析.
主要成果:
- 与HC相比,SCD和MCI组表现出左下顶叶 (IPL) 的体积减少.
- 与MCI相比,SCD患者在右下椎 (ITG),胰岛和杏仁体的形态发生了变化.
- 与MCI相比,在SCD中观察到右ITG,侧皮层 (LOC) 和胰岛的纤维通道的微观结构变化.
- 左侧IPL体积,右侧LOC体积,右侧杏仁体积和右侧LOC纤维通道扩散性与认知功能有显著的相关性.
结论:
- SCD和MCI在左IPL有共同的缩.
- 在SCD和MCI之间的皮层-亚皮层区域存在明显的形态和微观结构差异.
- 基于MRI的分类模型在区分这些组中实现了高精度 (>0.7,AUC=0.8).
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