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超稳定和可再分散的Zwitterionic瓶刷菌丝用于药物输送

Jeonghun Lee¹, Yao Tang², Karla E Cureño Hernandez¹

¹School of Materials Science and Engineering, Colorado State University, Fort Collins, Colorado 80523, United States.

ACS applied materials & interfaces

|October 7, 2024

概括

采用聚二甲基氧乙烯酸化胆 (PMPC) 贝的Zwitterionic瓶刷微粒对药物输送和生物成像的聚乙烯糖醇 (PEG) 类似物具有优越的稳定性. 在冷化和增强药物负载后,PMPC菌根表现出良好的再分散性.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

瓶刷共聚合物为自组装药物输送系统提供了增强的稳定性.
聚乙烯甘醇 (PEG) 广泛使用,但面临着关于免疫性方面的担忧.
对于先进的生物医学应用,需要使用替代的水友性区块化学.

研究的目的:

为了研究水友性块化学对瓶菌粒稳定性的影响.
为了比较zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) 和非离子PEG水友性块的性能.
评估PMPC菌根作为潜在的药物输送和生物成像剂.

主要方法:

用PMPC或PEG水友性块通过"从"聚合方式合成两性瓶刷.
自组装成球形小粒.
在各种具有挑战性的条件下进行稳定性测试 (高盐,洗剂,血清,温度,冷解/再悬浮).
多克索鲁比加载和释放研究.
血液相容性的评估.

主要成果:

与PEG类似物相比,在恶劣的条件下,PMPC外的瓶粉丝表现出优越的合体和拆卸稳定性.
在没有冷保护剂的冷化/再悬浮后,PMPC菌根显示出出色的再分散性.
兹维特菌菌体表现出更高的多克索鲁比负载能力和效率,释放延迟.
PMPC菌根是血液相容的,没有破坏红细胞膜.

结论:

兹维特里奥尼克PMPC瓶菌提供了出色的稳定性和血红相容性,超过了PEG类似物.
这些PMPC菌株是先进药物输送和生物成像应用的非常有前途的候选人.
PMPC固有的稳定性和有利的特性使其成为生物医学领域PEG的强大替代品.

关键词:

两的瓶子刷子两的瓶子刷子药物输送是药物输送的过程.再分散的纳米粒子.超稳定的纳米粒子.这种聚合物是zwitterionic聚合物.

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