综合性转录组和scRNA-seq分析揭示了SYNJ2在乳头甲状腺癌中的表达和潜在机制
Yuan-Ping Yang1, Zhi-Guang Huang1, Jia-Yuan Luo1
1Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
IET systems biology
|October 7, 2024
概括
赛纳普托亚宁2 (SYNJ2) 通过血管新生和上皮-甲状腺介质转变 (EMT) 促进乳头甲状腺癌 (PTC) 的进展. 高SYNJ2表达与患者对免疫疗法和化疗更好的反应相关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 目前尚不清楚Synaptojanin 2 (SYNJ2) 在乳头甲状腺癌 (PTC) 中的作用.
- SYNJ2与其他各种瘤类型的进展有关.
研究的目的:
- 研究PTC中SYNJ2的表达和功能.
- 探索SYNJ2表达与临床特征,生物途径,免疫透和PTC药物敏感性之间的关联.
主要方法:
- 对于SYNJ2蛋白表达的免疫组织化学.
- mRNA芯片和RNA测序用于SYNJ2的mRNA水平.
- 生物信息分析包括KEGG,GSVA,GSEA和单细胞RNA测序.
- 对免疫透,免疫检查点基因和药物敏感性的分析.
主要成果:
- 在PTC组织中,SYNJ2被显著上调,可以将PTC与非PTC组织区分开来.
- 高SYNJ2表达与丰富的血管新生和上皮细胞-介质细胞过渡 (EMT) 途径有关.
- 具有高SYNJ2表达的PTC患者对常见化疗药物的敏感性增加,免疫治疗反应更好.
结论:
- 通过激活血管生成和EMT通路,SYNJ2可能促进PTC进展.
- 在PTC患者中,SYNJ2可以作为预测治疗反应的潜在生物标志物.
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