在约束诱导运动治疗之前应用的有氧运动可以改变慢性中风后循环的分子生物标志物吗?
Luisa Fernanda García-Salazar1,2, Natalia Duarte Pereira1, Erika Shirley Moreira Silva1
1Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil.
Physiotherapy theory and practice
|October 7, 2024
概括
有氧运动 (AE) 与修改的约束诱导运动疗法 (mCIMT) 结合并没有改变脑衍生的神经营养因子 (BDNF) 或中风幸存者的虹膜素水平. 然而,AE确实增加了矩阵金属蛋白酶-9 (MMP-9) 活性,这表明潜在的心血管益处.
科学领域:
- 神经康复疗法 神经康复疗法
- 运动生理学 运动生理学
- 恢复的生物标志物 恢复的生物标志物
背景情况:
- 有氧运动 (AE) 可能通过调节神经营养因子,如脑衍生神经营养因子 (BDNF) 和虹膜素,改善中风后个体的运动恢复和心血管健康.
- 慢性中风的幸存者往往具有较高的矩阵金属蛋白酶-9 (MMP-9) 活性,这与运动功能的降低有关,但AE对这种生物标志物的影响尚不清楚.
研究的目的:
- 为了研究高强度AE训练在改性约束诱导运动疗法 (mCIMT) 之前对BDNF和虹膜素水平以及慢性中风幸存者的MMP-2和MMP-9活性的影响.
- 为了将这些分子变化与手工灵巧度和功能能力的改善相关联.
主要方法:
- 一组 (n=9) 接受了AE与mCIMT结合的为期两周的干预,而对照组 (n=7) 仅接受了mCIMT.
- 在干预之前和之后测量了BDNF和虹膜素的血清度,以及MMP-2和MMP-9活性.
- 用标准化测试评估手工敏捷性和功能能力干预前和后的标准化测试.
主要成果:
- 在不同组或随着时间的推移中,BDNF或素水平没有显著变化.
- 在AE组中,干预后的MMP-9活性显著增加 (p=0.033).
- 在手工敏捷度上有显著的改善,在评估和组对盒子和块测试有显著的主要影响,但在生物标志物变化和临床结果之间没有发现相关性.
结论:
- 在mCIMT之前整合AE并没有显著影响慢性中风幸存者的循环BDNF或虹膜蛋白水平.
- 然而,AE确实诱导了MMP-9活性的急性增加,这表明它可能在心血管重塑过程中发挥作用.
- 这些发现表明,虽然AE可能会影响某些生物标志物,但它对BDNF和虹膜素的直接影响在这种情况下需要进一步调查.
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