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Updated: Jun 11, 2025

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管道烟雾是否会在哺乳动物细胞中诱导基因毒性 (DNA损伤)? 一个系统的审查

Thiago Guedes Pinto¹, Fernando Augusto Cintra Magalhães¹, Ana Claudia Muniz Renno¹

¹Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, Sao Paulo, Brazil.

Toxicology mechanisms and methods

|October 7, 2024

概括

水管烟雾会对哺乳动物造成遗传损伤,这得到了15项研究的审查证实. 彗星和微核分析是监测水管用户的有效生物标志物.

科学领域:

毒理学毒理学毒理学
遗传学遗传学是一个
生物标志物生物标志物

背景情况:

水管是一种吸烟方式,涉及加热烟草并通过水吸入烟雾.
人们对水管烟雾暴露的潜在基因毒性存在担忧.
评估现有研究的质量对于可靠的结论至关重要.

研究的目的:

在生物体内评估水管烟雾在哺乳动物细胞中的基因毒性.
评估水管烟雾基因毒性的研究研究的质量和可靠性.
为生物监测水管用户确定合适的生物标志物.

主要方法:

使用PubMed,SCOPUS和Web of Science进行了全面的文献审查.
搜索包括到2024年7月发表的文章.
包括的研究被评估为质量和可靠性.

主要成果:

已证实,水管烟雾会诱导哺乳动物细胞中的遗传损伤.
大多数研究 (共15项研究中的11项) 符合强度或中度质量标准.
常见的DNA损伤包括链断裂,染色体损伤和氧化DNA损伤.

结论:

基因毒性测试在检测水管烟雾造成的DNA损伤方面是有效的.
彗星试验和微核试验是适合用于生物监测使用水管的人的生物标志物.
水管使用带来了显著的基因毒性风险.

关键词:

造成的DNA损伤是DNA损伤.水管是水管中的一部分.遗传毒性遗传毒性遗传毒性遗传毒性在活体中,活体中哺乳动物细胞哺乳动物细胞

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