生物药物处方和慢性鼻炎与鼻的手术的实践模式
Firas K Almarri1, Saad Algahtani2, Ghassan Alokby3,4
1Department of Otorhinolaryngology-Head and Neck Surgery, Ad Diriyah Hospital, Riyadh Third Health Cluster, Ministry of Health, Riyadh, Saudi Arabia.
American journal of rhinology & allergy
|October 7, 2024
概括
生物药物越来越多地用于患有鼻息肉的慢性鼻炎 (CRSwNP),减少了修复手术. 需要进一步的研究和教育,以优化CRSwNP管理的生物治疗策略.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 带有鼻息肉的慢性鼻炎 (CRSwNP) 提出了高复发率的管理挑战.
- 对患者生活质量的重大影响需要优化治疗策略.
- 对生物制剂的实际评估对于有效的CRSwNP管理至关重要.
研究的目的:
- 评估CRSwNP的现实世界生物使用和外科干预前景.
- 检查ARS成员之间的临床实践模式和生物采用.
- 评估生物制剂对CRSwNP管理中的外科实践的影响.
主要方法:
- 美国鼻科学会 (ARS) 162名会员的标准化问卷调查 (2022年7月至2023年8月).
- 对CRSwNP的生物处方和外科干预的临床实践模式的评估.
- 对生物可访问性,对手术的影响和表型特异性治疗考虑的数据的分析.
主要成果:
- 95%的参与者为CRSwNP处方生物药物,45%的人报告易于获得.
- 36%观察到由于生物药物的修复鼻手术减少.
- 亚司匹林恶化呼吸道疾病 (AERD) 被确定为生物治疗的关键表型; 58%的人使用患者报告结果测量 (PROM).
结论:
- 生物治疗越来越多地被纳入CRSwNP管理中.
- 生物药物显示出减少修复手术需求的趋势.
- 持续的研究,指南更新和从业人员教育对于优化CRSwNP护理至关重要.
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