振荡式空气流通过下喉和上喉气道
L Reid1,2, M Hayatdavoodi2
1Brighton and Sussex Medical School, University of Sussex, England, UK.
Computer methods in biomechanics and biomedical engineering
|October 7, 2024
概括
运动诱导的喉阻塞 (EILO) 是由内侧喉组织崩引起的. 这项研究表明,呼吸强度,而不是频率,通过改变空气流动力学来影响EILO的气道关闭.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 生物医学工程 生物医学工程
- 流体动力学 流体动力学
背景情况:
- 运动诱导的喉阻塞 (EILO) 通过喉组织崩引起运动性呼吸不良.
- EILO的确切机制尚不清楚,但怀疑组织对空气流负荷的抵抗性降低.
- 目前关于喉气流的研究仅限于稳定,单向的气流,忽视了呼吸的循环性质.
研究的目的:
- 研究振荡式空气流对喉流场和空气诱导负荷的影响.
- 了解呼吸模式在EILO病理生理学的作用.
- 分析上呼吸道 (URT) 的空气流动力学如何为EILO做出贡献.
主要方法:
- 使用雷诺兹-平均纳维埃-斯托克斯方程开发了URT的计算流体动力学 (CFD) 模型.
- 模拟了五种振荡式空气流场景,其呼吸频率不同 (24-40次/分钟) 和最高吸气流量 (96-240升/分钟).
- 分析了空气流速分布,压力和对URT壁和喉结构的力.
主要成果:
- 在URT中的灵感速度分布取决于呼吸频率和强度.
- 在URT墙壁上的力量与空气流速相应,表现出准稳定的行为.
- 在aryepiglottic上引起的空气力量表明,呼吸强度,而不是频率,影响了EILO中的supraglottic关闭.
结论:
- 振荡式空气流显著影响喉流动力学和空气诱导的负荷.
- 呼吸强度是空气诱导的关闭的关键因素,在EILO观察到的supraglottis.
- 研究结果表明,EILO的治疗策略应该考虑呼吸强度对喉机制的影响.
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