老年人中大动脉骨硬度梯度和心血管风险
Keeron Stone1,2, Simon Fryer3, Barry J McDonnell1,2
1Centre for Cardiovascular Research, Innovation and Development, Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Wales, United Kingdom (K.S., B.J.M., C.J.A.P.).
Hypertension (Dallas, Tex. : 1979)
|October 7, 2024
概括
大动脉-关节动脉硬度梯度是动脉硬度的度量,可以预测老年人心血管疾病 (CVD) 风险. 这项研究发现,硬度梯度,而不是仅仅脉冲波速度,与发生的心血管疾病有关.
科学领域:
- 心血管医学 心血管医学
- 血管生物学 血管生物学
- 老年医学 老年医学
背景情况:
- 通过脉冲波速度 (PWV) 测量的动脉硬与心血管疾病 (CVD) 风险有关.
- 大动脉-大腿动脉硬度梯度 (下肢PWV/大动脉PWV) 是评估心血管疾病风险的新型指标.
- 这种梯度对于发生心血管疾病的预测值在很大程度上是未知的.
研究的目的:
- 调查大动脉-大腿动脉硬度梯度测量与发生心血管疾病之间的关联.
- 为了确定阴道-股骨和心-股骨硬度梯度是否预测心血管疾病事件和全因死亡率.
- 评估PWV和刚度梯度在心血管疾病风险分层中的作用.
主要方法:
- 社区动脉样硬化风险研究队列包括3109名无心血管疾病的参与者.
- 计算了带-关节硬度梯度和心-关节硬度梯度.
- 考克斯回归模型分析了与中位数7.4年随访期间发生心血管疾病和死亡率的关联.
主要成果:
- 阴道-关节和心-关节硬度梯度较高的四分位数与发生心血管疾病的风险增加有关.
- 高大动脉硬度和低下肢硬度的组合显著预测了事件CVD.
- 仅仅脉冲波速度并没有显著与发生心血管疾病或全因死亡率有关.
结论:
- 大动脉-股骨动脉硬度梯度显示了提高老年人心血管疾病风险评估的潜力.
- 这种梯度可能会提供超越传统风险因素和PWV的附加预测价值.
- 刚度梯度,特别是心股骨尺度,是该队列中发生心血管疾病的显著预测因素.
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