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在HIV患者用逆转录酶抑制剂治疗期间的肝损伤

Giorgiana Nicoleta Lungu¹, Gheorghe Iulian Diaconescu^2,3, Florentina Dumitrescu^2,4

¹Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.

Current health sciences journal

|October 7, 2024

概括

高活性抗逆转录病毒疗法 (HAART) 改善了艾滋病毒的存活率,但有些药物可能会导致肝损伤. 定期监测肝脏和调整治疗对于艾滋病毒感染者 (PLWH) 来说至关重要.

科学领域:

传染性疾病传染性疾病
肝病学肝病学是一种肝病学.
药理学药理学是指药理学的学科.

背景情况:

高活性抗逆转录病毒疗法 (HAART) 在1996年后显著改善了艾滋病毒感染者 (PLWH) 的预期寿命.
反转录酶抑制剂 (RTIs) 是HAART的关键组成部分,通过抑制反转录酶酶来破坏HIV复制.
在PLWH的死亡原因已经从机会性感染转移到肝病和心血管并发症.

研究的目的:

审查与核酸和非核酸逆转录酶抑制剂相关的肝毒性风险,用于HAART.
突出不同抗逆转录病毒药物之间不同程度的肝损伤潜力.
强调监测PLWH肝脏健康和管理抗逆转录病毒疗法以减轻纤维化风险的重要性.

主要方法:

文献综述侧重于抗逆转录病毒疗法的肝毒性.
对不同类逆转录酶抑制剂相关风险的分析.
检查增加肝毒性风险的因素,例如与乙型肝炎或型肝炎病毒的同时感染.

主要成果:

抗逆转录病毒疗法,特别是某些RTIs,可以在PLWH中引起严重的肝损伤.
不同的抗逆转录病毒药物之间,肝毒性风险差异很大.
同时感染B型肝炎或C型肝炎病毒会大大增加药物诱导的肝损伤的风险.

结论:

定期监测肝功能对于接受HAART的PLWH至关重要.
选择抗逆转录病毒药物和调整治疗方案是必要的,以尽量减少肝纤维化风险.
了解药物特异性肝毒性对于管理艾滋病毒感染者长期肝脏健康至关重要.

关键词:

艾滋病病毒艾滋病病毒艾滋病病毒肝毒性肝毒性肝毒性线粒体功能障碍线粒体功能障碍逆转录酶抑制剂的使用

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