跨越九种精神疾病的选择性交配在文化和世代之间是一致和持久的
medRxiv : the preprint server for health sciences
|October 7, 2024
概括
精神疾病的选择性交配 (AM) 在文化和世代之间是一致的. 这项分析数百万人的研究揭示了AM.
科学领域:
- 行为遗传学行为遗传学
- 精神病学流行病学精神病学流行病学
- 人类生殖行为人类的生殖行为.
背景情况:
- 选择性交配 (AM),即具有相似特征的个体之间的非随机交配,显著影响了复杂的人类特征的遗传结构.
- 抗精神病可以提高疾病患病率,影响并发症模式,并引入偏见在估计遗传影响精神疾病的偏见.
- 关于AM的文化变异和代际趋势的有限的大规模研究存在,特别是针对精神疾病.
研究的目的:
- 在九种精神疾病中进行各种交配 (AM) 的最大规模分析.
- 通过对台湾,丹麦和瑞典的数据进行元分析来调查AM的文化差异.
- 检查1930年代之后出生的个人对AM的代际趋势.
主要方法:
- 利用国家注册数据集进行全面分析.
- 分析了多达140万个匹配病例和600万个匹配对照.
- 进行了元分析,以比较不同国家和不同世代的AM估计.
主要成果:
- 精神疾病的各种交配 (AM) 模式在研究国家 (台湾,丹麦,瑞典) 发现是一致的.
- 精神疾病的AM表现出跨世代的持续性,在20世纪30年代之后出生的人群中观察到的变化很小.
- 一小部分疾病在AM模式中表现出轻微的代际变化.
结论:
- 综合性交配 (AM) 是一个稳定的因素,在不同的文化背景和随着时间的推移影响精神疾病.
- 这些发现提供了对精神疾病中AM背后的机制的关键见解.
- 结果对准确估计精神疾病的遗传结构有重大影响.
相关概念视频
Behavioral Genetics and Its Designs
337
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
337
Psychological and Sociocultural Causes of Schizophrenia
80
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
80
Evolutionary Psychology
253
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
253
Human Genetics
540
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
540
Theoretical Approaches to Psychological Disorder
117
The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
117
Diagnostic and Statistical Manual of Mental Disorders (DSM)
48
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
48


