抗生素子类差异性地扰乱了移植接受者的肠道微生物群
Hanbo Dong1, Runzhe Li2, Ni Zhao2
1Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Frontiers in transplantation
|October 7, 2024
概括
抗生素的使用显著改变了移植接受者的肠道微生物群,减少了多样性并改变了细菌的丰富性. 这些变化可能会增加感染风险.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 移植 移植 移植 移植
背景情况:
- 肠道微生物群在宿主健康中起着至关重要的作用,特别是在免疫功能低下的个体中,如移植接受者.
- 各种抗生素子类对这种脆弱人群的肠道微生物群的影响仍然不太清楚.
研究的目的:
- 调查不同抗生素子类对肠道微生物群组成和移植受体多样性的影响.
- 在这个队列中识别受抗生素暴露影响的特定细菌种群.
主要方法:
- 使用V4-V5高变区的16SrRNA基因测序,对510个便标本的肠道微生物组进行了分析.
- 标本根据抗生素暴露分类:β-乳酸,化 (FQ),β-乳酸和FQ组,其他抗生素和没有抗生素 (没有Abx).
- 混合效应回归模型被用于分析微生物多样性和属丰度的变化,并对共变量进行调整.
主要成果:
- 抗生素的使用与香农α多样性的显著减少有关.
- 观察到11种细菌种群的减少,包括Eubacterium和Ruminococcus,以及16种种种群的增加,如Enterococcus和Staphylococcus.
- 暴露于β-乳会增加Enterococcus和减少Eubacterium,而暴露于FQ会影响7种种类,包括Ruminococcus.
结论:
- 贝塔乳和诺基诺抗生素对脏移植接受者的肠道微生物群产生深远的影响.
- 由于抗生素导致肠道微生物群的改变可能会增加这些患者随后感染并发症的风险.
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