超越芬太尼测试条:研究其他尿液药物测试条用于药物检查应用
Edward Sisco1, Meghan G Appley1, Elise M Pyfrom1
1National Institute of Standards and Technology, Gaithersburg, MD, USA.
Forensic chemistry (Amsterdam, Netherlands)
|October 7, 2024
概括
尿液免疫测试试卷显示出药物检查的前景,检测出微量 fentanyl 和 xylazine 等物质. 然而,交叉反应性需要仔细解释,以便准确的药物检查应用程序.
科学领域:
- 法医科学 法医科学 法医科学
- 分析化学 分析化学
- 公共卫生 公共卫生
背景情况:
- 药物检查服务越来越多地使用免疫测试试卷来检测芬太尼和西拉.
- 扩大药物检查需要评估现有的尿液测试条的实用性,以便直接分析药物产品.
研究的目的:
- 调查七种类型的尿液免疫测试试卷在药物检查应用中的适用性.
- 评估这些试验条的可复制性,灵敏性,交叉反应性和热稳定性.
主要方法:
- 评估了七个尿液免疫测试试卷 (安非他林,二,可卡因,甲基安非他林,尼塔,阿片类药物,西拉) 用于药物检查.
- 评估了可重现性,灵敏度 (微克/毫升水平),交叉反应性和高温的影响.
- 测试过期测试条的可行性.
主要成果:
- 试验条通常是可重现的,并且对追踪分析剂水平敏感.
- 大多数测试显示,在高温下长时间储存的影响很小.
- 与非目标化合物观察到显著的交叉活性,过期的条纹保持了灵敏度.
结论:
- 尿液免疫测试试卷可以检测药物样本中的标分析物,但表现出交叉反应性.
- 了解交叉反应性对于药物检查中的准确解释至关重要.
- 过期的试验条可能仍然是可行的,但建议进一步验证.
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