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基因组和空间分析在中国东部的近期传播的菌根结核病:一个10年的追溯基于人口的研究

Xiwen Yin¹, Qiang Zhang¹, Yuting Wang¹

¹Department of Epidemiology, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education Institutions in Jiangsu Province, Center for Global Health, School of Public Health, Nanjing, 211166, People's Republic of China.

Infection and drug resistance

|October 7, 2024

概括

全基因组测序揭示了10年来中国东部的Mycobacterium结核病传播高风险地区和人群. 有针对性的预防策略对于控制结核病 (TB) 爆发至关重要.

科学领域:

基因组学就是基因组学.
流行病学流行病学
公共卫生公共卫生

背景情况:

了解结核菌 (M. tuberculosis) 传播对于有效的疾病控制至关重要.
全基因组测序 (WGS) 提供了比传统方法更高的分辨率来追踪感染源和传播途径.
解决广泛的结核病 (TB) 疫情需要详细的遗传信息.

研究的目的:

在中国东部十年内调查M.结核病的传播模式.
确定高风险人群和地理区域的M.结核病传播.
利用全基因组测序来加强疫情调查和来源追踪.

主要方法:

一项为期十年 (2011-2020年) 的研究在中国东部的连云港,涉及2252个M.结核病分离体.
全基因组测序 (WGS) 在M.结核菌株上进行.
基因组集群是由双向遗传距离 (<12个SNP) 定义的,这表明最近的传播.
核心密度估计和K函数分析被用来评估空间分布.

主要成果:

分析了2114种M.结核菌株,主要是2系 (75.35%) 和4系 (24.65%).
观察到最近的传播率为31.79%,有672个聚类菌株.
学生 (aOR: 2.68) 和那些感染L2.2.1菌株 (aOR: 1.59) 的人显示出最近传播的风险增加.
结核病传播在海州,东海和关地区的空间聚合率较高,发现了三起爆发.

结论:

在研究地点的特定区域和人群具有M.结核病传播的高风险.
在不同的人口群体中,结核病传播的风险差异很大.
针对特定地区和关键人群的有针对性的预防策略对于制结核病患病率至关重要.

关键词:

集群集群是一个集群集群.空间分析就是空间分析.传输传输传输传输传输传输结核病是一种肺结核病.整个基因组的测序.

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