在种族和少数民族群体中结直肠腺癌的生存差异:A SEER数据库研究
Arvin Jeremy Tan1, Chuong Tran2, Nurlan Aliyev3
1Department of Internal Medicine, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (AJNT).
Hawai'i journal of health & social welfare
|October 7, 2024
概括
在结直肠癌 (CRC) 存活率方面,种族差异仍然存在,黑人患者面临着明显更糟糕的结果. 了解这些差异对于制定有针对性的策略来提高所有少数群体CRC存活率至关重要.
科学领域:
- 在瘤学瘤学.
- 健康差异 在健康上的差异
- 流行病学 流行病学
背景情况:
- 结直肠癌 (CRC) 存活率的种族和民族差异仍然是一个重要的公共卫生问题,尽管医疗保健取得了进展.
- 现有研究表明,不同种族和少数民族群体的生存率各不相同,因此需要详细描述这些差异.
研究的目的:
- 分析和比较美国不同种族和少数民族的结肠直肠癌 (CRC) 存活率.
- 确定这些群体中与CRC生存差异相关的人口,临床和社会经济因素.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库提取2015年至2019年期间诊断的成人CRC患者的数据.
- 采用卡普兰-梅尔生存分析和考克斯比例危险模型来评估生存差异并确定显著的预后因素.
- 提取和分析了西班牙裔,黑人,东南亚人,中国人,美洲印第安人和阿拉斯加原住民 (AIAN),亚洲印第安人和巴基斯坦人 (AIP) 以及夏威夷原住民和其他太平洋岛民 (NHOPI) 人口的人口统计,疾病特征,手术治疗和社会经济地位的数据.
主要成果:
- 确定了1年生存率的显著变化,在西班牙裔,黑人和AIAN人群中观察到较低的比率.
- 多变量分析显示,与AIAN患者相比,黑人患者的死亡风险比率 (HR) 显著更高 (HR: 1.21).
- 与较差的CRC存活率相关的因素包括年龄较大,疾病晚期,家庭收入较低 (<60,000美元),男性性别以及缺乏手术干预.
结论:
- 结直肠癌 (CRC) 存活率仍然存在显著的种族和民族差异,特别影响黑人和西班牙裔人口.
- 社会经济因素,疾病阶段和治疗机会在这些生存差异中起着至关重要的作用.
- 进一步的研究是必不可少的,以了解潜在的原因,并制定有效的干预措施,以减少少数群体之间的CRC生存差异.
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