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血清介质素-6作为创伤并发症的早期指标

Aparna Laishram¹, Alice Ruram¹, Bhaskar Borgohain²

¹Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.

|October 7, 2024

概括

血清干白素-6 (IL-6) 有效地预测创伤并发症. 在24小时内IL-6水平升高显示了创伤患者早期风险评估的高灵敏度和特异性.

科学领域:

生物化学生物化学
临床医学临床医学
生物标志物发现发现

背景情况:

创伤是全球死亡和发病的主要原因.
早期识别高风险创伤患者对于改善结果至关重要.
血清介质素-6 (IL-6) 是一种关键的炎症性细胞因子,具有作为创伤生物标志物的潜力.

研究的目的:

评估血清IL-6作为创伤相关并发症的早期预测生物标志物.
评估IL-6水平,损伤严重程度和其他炎症标志物之间的相关性.
确定创伤患者IL-6测量的最佳时间点.

主要方法:

119名创伤患者 (19-65岁) 的前性观察队列研究.
血清IL-6和C反应蛋白 (CRP) 在创伤后12小时和24小时测量.
评估了受伤严重程度得分 (ISS) 和多器官功能障碍得分 (MODS,qSOFA).

主要成果:

21.85%的患者出现并发症,主要是不明显的缺氧.
在12小时和24小时出现并发症的患者中观察到显著升高的IL-6水平 (p < 0.001).
在24小时后,IL-6显示出对并发症的高灵敏度 (96.2%) 和特异性 (87.1%),截止值为55.08 pg/mL. 在24小时内IL-6与ISS (r=0.725) 和CRP (r=0.749) 之间存在强烈的相关性.

结论:

血清IL-6是早期发现创伤并发症的有价值的生物标志物.
IL-6水平与创伤严重程度 (ISS) 和炎症 (CRP) 有显著的相关性.
创伤后24小时IL-6测量为不良结果提供了高预测价值.

关键词:

并发症可能导致并发症.伤害严重程度得分是多少介质蛋白 (il) -6 的存在.灵敏度和特异性灵敏度和特异性创伤的创伤创伤的创伤.

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