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相关概念视频

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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相关实验视频

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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
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载有CBD的纳米结构脂质载体:优化,表征和稳定性

Yang Xie1, Peng Li1, Dong Fu1

  • 1Heilongjiang Academy of Sciences, Institute of Advanced Technology, Harbin 150020, China.

ACS omega
|October 7, 2024
PubMed
概括

纳米结构脂质载体 (CBD-NLC) 是为了改善大麻 (CBD) 的稳定性和可溶性而开发的,用于增强抑郁症治疗. 这些CBD-NLC显示出对制药和食品应用的希望.

科学领域:

  • 制药纳米技术 制药纳米技术
  • 药物输送系统 药物输送系统
  • 大麻素研究 研究 大麻素研究

背景情况:

  • 大麻 (CBD) 显示了抑郁症的治疗潜力,但面临着像溶解性和稳定性差等挑战.
  • 多态性,有限的水溶性和肝脏第一通代谢阻碍了CBD的临床应用.
  • 需要新的输送系统来克服这些局限性并提高CBD的疗效.

研究的目的:

  • 开发和优化含有CBD的纳米结构脂质载体 (CBD-NLCs),以提高CBD的化学稳定性和水溶性.
  • 描述开发的CBD-NLCs的物理化学特性和稳定性.
  • 评估CBD-NLCs在食品强化和制药中的释放特征和潜在应用.

主要方法:

  • CBD-NLCs使用热化乳化制备,并通过响应表面方法 (RSM) 进行优化,采用Box-Behnken设计.
  • 配方的特点是颗粒大小,多分散度指数 (PDI),泽塔潜力和封装效率.
  • 使用扫描和传输电子显微镜 (SEM/TEM) 评估了形态学;还评估了稳定性和药物释放动力学.

主要成果:

  • 优化的CBD-NLCs的平均颗粒大小为54.33nm,PDI为0.118,泽塔电位为-29.7mV,封装效率为87.58%.
  • 电子显微镜证实了球形纳米粒子形态.

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  • CBD-NLCs表现出增强的光稳定性,在42天内保持完整性,并显示出双相释放模式 (初始爆发后持续释放).

    • 结论:

    • 开发的CBD-NLC有效地提高了CBD的稳定性和可溶性,解决了治疗用途的关键限制.
    • 该配方的理想特征和受控释放特征表明CBD在制药和食品强化应用中的输送潜力很大.
    • 这种纳米结构的脂质载体系统为改善大麻的生物可用性和治疗疗效提供了一个有希望的策略.