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Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

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新型温度响应的聚合物基密封剂用于栓塞.

Ali E Dabiri¹, Ravin Narain², Yi-Yang Peng²

¹3DTholdings, San Diego, CA, USA.

Science and technology of advanced materials

|October 7, 2024

概括

此摘要是机器生成的。

一种新的水凝密封剂提供了改进的导管治疗,有效的输送和没有有害的副产品. 这种可调节的聚N-异烯胺 (PNIPAM) 材料是安全的,具有成本效益,适用于淋巴泄漏栓塞和左心房附属物排除.

关键词:

粘合剂粘合剂粘合剂心房动是心房动的一种.可以注射的水凝.淋巴泄漏是指淋巴泄漏的情况.自愈的水凝可以自愈.

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科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
医疗设备工程医疗设备工程

背景情况:

目前以导管为基础的治疗方法在输送效率,现场聚合,副产品安全性和成本方面存在局限性.
需要先进的密封材料,这些材料可以调节,安全和有效,用于各种医疗应用.

研究的目的:

开发和表征一种基于聚烯-N-异烯胺 (PNIPAM) 的新型水凝密封剂,其对以导管为基础的干预措施具有改善的特性.
评估材料适用于特定应用的适用性,例如淋巴泄漏栓塞和左心房附属体 (LAA) 排除.

主要方法:

利用基于模型的开发和材料测试来优化热敏的PNIPAM水凝.
对可调节过渡温度,放射透明度,用于3Fr导管输送的机械性能和凝聚力强度的水凝进行了表征.
评估了安全性概况和现场聚合和有害副产品的可能性.

主要成果:

开发了一种具有定制过渡温度,适当的辐射透明度和适合导管输送的机械性能的水凝密封剂.
在生理压力下表现出足够的凝聚力来抵抗迁移,并提高了安全性.
在淋巴泄漏栓塞和LAA排除中确定了潜在的应用,以减轻血栓栓塞事件.

结论:

开发的基于PNIPAM的水凝密封剂比现有技术提供了显著的改进.
该材料的可调节性质,安全性和有效性使其成为研究示例之外的各种医疗保健应用的有希望的候选者.