在ferroptotic环境中的炎症.
Anja Wickert1, Anna Schwantes1, Dominik C Fuhrmann1,2
1Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.
Frontiers in pharmacology
|October 7, 2024
概括
铁,一种依赖于铁的细胞死亡,越来越多地研究其在炎症中的作用. 这篇评论探讨了炎症途径和铁代谢如何影响免疫细胞铁.
科学领域:
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 铁亡是一种受调节的细胞死亡途径,由铁的积累和脂质过氧化驱动.
- 铁亡,炎症和免疫细胞功能之间的复杂关系仍然不完全理解.
- 关键的炎症途径,如NF-κB和HIFs,都与调节铁亡的易感性有关.
研究的目的:
- 在炎症的背景下审查目前对铁亡的理解.
- 为了阐明炎症状况对免疫细胞ferroptosis的影响.
- 探索炎症期间免疫细胞中铁代谢和铁的相互作用.
主要方法:
- 对研究铁亡,炎症和免疫力的文献综述.
- 对将炎症信号与铁亡联系起来的分子机制的分析.
- 在炎症刺激下检查免疫细胞中铁代谢变化的检查.
主要成果:
- 炎症途径显著影响铁亡的调节.
- 免疫细胞,包括巨细胞和中性粒细胞,在炎症期间表现出改变的铁代谢.
- 这些代谢变化会影响免疫细胞对铁亡的敏感性.
结论:
- 铁亡在炎症过程中起着复杂的作用.
- 了解铁代谢转变对于理解炎症期间免疫细胞铁亡至关重要.
- 需要进一步的研究,以充分界定向炎症性疾病中的铁亡的治疗潜力.
相关概念视频
Necrosis
4.4K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.4K
Microbial Nutrition
3
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
3
Phagocytosis of Apoptotic Cells
3.7K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...
Normal cells contain receptors that prevent them from being recognized...
3.7K
Ferromagnetism
2.4K
Materials like iron, nickel, and cobalt consist of magnetic domains, within which the magnetic dipoles are arranged parallel to each other. The magnetic dipoles are rigidly aligned in the same direction within a domain by quantum mechanical coupling among the atoms. This coupling is so strong that even thermal agitation at room temperature cannot break it. The result is that each domain has a net dipole moment. However, some materials have weaker coupling, and are ferromagnetic at lower...
2.4K
Inflammation
53.2K
Overview
53.2K
Overview of Cell Death
7.1K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
7.1K


