碳水化合物限制引起的LDL胆固醇和动脉样硬化的升高:KETO试验
Matthew Budoff1, Venkat S Manubolu1, April Kinninger1
1Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
JACC. Advances
|October 7, 2024
概括
与对照组相比,性饮食中高LDL胆固醇 (瘦体过度反应者) 的人没有增加冠状动脉斑块. 这表明,在饮食中高的LDL-C可能不会在这个人群中加速动脉样硬化.
科学领域:
- 心血管疾病研究研究
- 代谢健康研究 代谢健康研究
- 营养科学 营养科学
背景情况:
- 碳水化合物限制的性饮食可以提高低密度脂蛋白胆固醇 (LDL-C).
- 瘦身,健康个体的一个子集,称为瘦身,健康个体.
- 瘦质超响应器的超响应器
- (LMHR),在这些饮食中表现出特别高的LDL-C.
研究的目的:
- 为了比较LMHR个体之间的冠状动脉斑块负担,在基因饮食和匹配的对照中增加了LDL-C.
- 调查高LDL-C水平和LMHR个体的冠状动脉斑块之间的关系.
主要方法:
- 使用冠状动脉评分和冠状动脉计算机断层扫描血管学 (CCTA).
- 对比了80个基因饮食 (KETO) 个体 (LDL-C ≥190 mg/dL) 与来自迈阿密心脏 (MiHeart) 队列的匹配对照 (较低的LDL-C).
- 控制年龄,性别,种族,高脂血症,高血压和吸烟状况.
主要成果:
- 在KETO组和对照组之间没有发现冠状动脉斑块负担的显著差异.
- 冠状动脉分数 (中位数为0比1) 和CCTA总斑块分数 (中位数为0比0) 在各组之间相似.
- 在任何一组中都没有观察到LDL-C水平和冠状动脉斑块负担之间的相关性.
结论:
- 具有较高LDL-C (≥190 mg/dL) 的代性饮食的新陈代谢健康个体没有比匹配的对照表现出更大的冠状动脉斑块负担.
- 在这个LMHR队列中,LDL-C水平和冠状动脉斑块负担之间没有联系.
- 来自饮食诱导的LDL-C升高和动脉样硬化进展 (Keto-CTA) 研究的发现.
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