新辅助化疗后晚期胃癌 laparoscopic 与开放手术的效果:一个元分析
Kun Huang1,2, Jie Zhong1,2, Dequan Jiang1,2
1Department of General Surgery, Central Hospital of Jiangjin District, Chongqing 400000, China.
Journal of healthcare engineering
|October 7, 2024
概括
经过新辅助化疗后,晚期胃癌的 laparoscopic 手术显示出减少出血和较短的住院时间与开放手术相比. 长期存活率仍然相当,这证实了腹腔镜检查.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 先进的胃癌治疗通常涉及新辅助化疗,随后是手术切除.
- 手术方法包括腹腔镜和腹腔切除术,每个都有不同的潜在好处和缺点.
研究的目的:
- 进行一项元分析,评估腹腔镜手术与开放 (腹腔切除) 手术对晚期胃癌后新辅助化疗的疗效.
- 为了比较两个手术技术之间的关键的术后和长期结果.
主要方法:
- 在Cochrane图书馆,Embase和PubMed进行了系统的文献搜索,截至2021年12月1日.
- 来自11项涉及1027名患者 (413名腹腔镜,614名开放) 的研究数据被提取并使用RevMan 5.3.3进行分析.
主要成果:
- 腹腔镜手术与明显减少手术内出血,更早的术后恢复 (排气) 和更短的住院时间有关.
- 腹腔镜组的手术时间更长,但淋巴结解剖,30天的并发症率或第一次排便/养的时间没有显著差异.
- 在腹腔镜和开放组之间,三年总生存率没有显著差异.
结论:
- 与开放式手术相比,晚期胃癌的 laparoscopic 手术在 neoadjuvant 化疗后提供了减少血液损失,更短的住院时间和更快的恢复的优势.
- 这些发现支持腹腔镜方法的安全性和有效性,具有可比的长期瘤结果.
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