里图西马布诱导肺部的罕见囊性损伤在一个瘤儿童:一个案例报告
Subal K Pradhan1, Snehamayee Nayak1
1Division of Pediatric Nephrology, SVP Post Graduate Institute of Pediatrics (SVPPGIP) and Sriram Chandra Bhanja (SCB) Medical College, Cuttack, Odisha, India.
Indian journal of nephrology
|October 7, 2024
概括
这项案例研究突出了一个罕见的例例,里图西马布诱导的肺损伤在患有性综合征的儿童. 及时的类固醇治疗导致完全康复,强调考虑这种不良影响的重要性.
科学领域:
- 儿科脏病学 儿科脏病学
- 肺部病理学 肺部病理学
- 药物监督 药物监督 药物监督
背景情况:
- 抗CD20单克隆抗体瑞图西马布 (Rituximab) 越来越多地用于频繁复发或类固醇依赖性性综合征.
- 虽然通常是安全的,但在成年人中记录了罕见的肺部不良事件,在儿童群体中报告有限.
研究的目的:
- 报告一个罕见的Rituximab诱导的肺损伤病例,该病例发生在患有频繁复发性性综合征的儿科患者身上.
- 强调考虑rituximab作为儿童肺部并发症的潜在原因的重要性.
主要方法:
- 一个9岁男孩的病例报告,患有频繁复发性瘤综合征.
- 详细的临床观察Rituximab输注后出现的呼吸道症状.
- 诊断工作,包括排除感染和败血症.
- 类固醇治疗的治疗试验.
主要成果:
- 在Rituximab输注四天后,患者出现呼吸道症状,最初怀疑是感染/败血症.
- 广泛的抗生素,抗真菌药物和抗结核治疗是无效的.
- 停止抗生素和启动类固醇治疗导致肺部症状完全消失.
- 这是印度儿童首次报告Rituximab诱导的囊性肺病变病例.
结论:
- 利图西马布可以在患有性综合征的儿科患者中引起罕见但显著的肺损伤.
- 早期怀疑和及时的类固醇治疗对于管理Rituximab诱导的肺损伤至关重要.
- 这一案例扩大了对rituximab在儿童肺部不良影响的理解.
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