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临床移植功能损失由于小肠细菌过度生长
Tomoo Kise1, Masatsugu Uehara1
1Division of Paediatric Nephrology, Okinawa Prefectural Nanbu Medical Centre, Children's Medical Centre, Haebaru, Japan.
Indian journal of nephrology
|October 7, 2024
概括
小肠细菌过度生长 (SIBO) 在移植患者中可能导致严重的腹和低血压休克. 抗生素轮换疗法是这种人群中复发性SIBO的潜在治疗方法.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 小肠细菌过度生长 (SIBO) 的特点是小肠内细菌过多,导致腹等胃肠症状.
- SIBO带来了诊断和治疗方面的挑战,特别是在免疫功能低下的患者中,例如移植患者.
研究的目的:
- 报告小儿移植患者SIBO诱导的低血压休克病例.
- 为诊断和管理SIBO移植接受者的严重腹提供见解.
主要方法:
- 一名14岁的移植接受者出现了严重的,反复出现的腹和低血压休克.
- 治疗涉及体积加载,连续血液过和连续的抗生素治疗,包括利法西明,阿莫西西林/克拉夫兰酸和西普罗夫洛克萨.
- 诊断评估包括上部内镜和乳糖呼吸试验.
主要成果:
- 最初的抗生素治疗是无效的;然而,一个连续的抗生素旋转方案成功地管理了复发性腹.
- 患者经历了归因于SIBO的低血压休克,需要透析.
- 尽管乳糖呼吸试验呈阴性,但临床表现强烈表明SIBO.
结论:
- 在患有胃肠道症状,特别是严重腹的移植患者中,应考虑SIBO.
- 连续的抗生素轮换疗法可能是一种有效的策略,用于管理SIBO在免疫抑制患者.
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