长时间的中度到剧烈的体力活动可能导致认知表现下降:孟德尔的随机化研究
Yutao Li1, Chenyi Fu2, Honglin Song2
1School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
Frontiers in aging neuroscience
|October 7, 2024
概括
这项研究发现,较高水平的中度至剧烈的体力活动 (MVPA) 与较差的认知表现有遗传联系. 这些发现表明MVPA与认知功能之间存在潜在的负面因果关系.
科学领域:
- 遗传学和人类健康
- 神经科学与认知功能
- 公共卫生和体力活动
背景情况:
- 人们普遍认为,体育活动有益于认知功能.
- 然而,因果关系仍然存在争议,需要进行严格的调查.
- 遗传关联研究提供了探索这种因果关系的工具.
研究的目的:
- 调查中度至剧烈体力活动 (MVPA) 与认知表现之间的潜在因果关系.
- 使用孟德尔随机化 (MR) 分析,利用与MVPA相关的遗传变异.
主要方法:
- 进行了两样本的孟德尔随机化分析.
- 来自GWAS的MVPA的基因位点作为仪器变量.
- 认知表现的遗传数据来自单独的GWAS;使用逆方差加权 (IVW),加权中位数和MR-Egger回归.
主要成果:
- 逆方差加权 (IVW) 显示,基因预测的MVPA与认知表现之间存在显著的负相关性 (Beta = -0.551,p < 0.001).
- 在多种MR方法中观察到一致的反向关联,包括加权中位数和MR-Egger回归.
- 多变量MR分析,对BMI,吸烟,睡眠和酒精进行调整,证实了显著的负相关性 (Beta = -0.599,p < 0.001).
结论:
- 基因预测中度至强度的体力活动与认知表现有显著的反向关联.
- 这些发现表明,更高的基因预测MVPA可能与认知功能下降有因果关系.
- 需要进一步的研究来阐明这种意想不到的关系背后的机制.
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