确定肺癌查干预的优先人群,使用社区层面的因素和癌症登记数据
Meghan Tipre1,2, Celeste Picone2, Kathryn Demanelis1,2
1Division of Hematology Oncology, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
概括
社区贫困显著增加了肺癌 (LC) 风险和死亡率. 在高贫困地区的有针对性的干预措施对于减少LC健康差异至关重要.
科学领域:
- 环境流行病学环境流行病学
- 公共卫生 公共卫生
- 癌症研究 癌症研究
背景情况:
- 肺癌 (LC) 发病率和死亡率呈现出地理差异.
- 社区层面的社会经济,环境和社会因素可能会影响LC风险.
研究的目的:
- 评估社区水平指标与肺癌 (LC) 发病率和死亡率之间的关联.
- 识别与LC风险增加相关的特定社区特征.
主要方法:
- 利用了来自美国宾夕法尼亚州阿勒盖尼县3256例成年LC病例 (2015-2019) 的数据.
- 将LC病例数据与社区贫困指数 (NDI),建筑环境和种族隔离的人口普查数据联系起来.
- 采用波桑回归来计算LC发病率和死亡率的相对风险 (RR),调整为共变量.
主要成果:
- 社区贫困指数 (NDI) 的五分位数增加与较高的LC发病率和死亡率有显著的关联.
- 与最低五分位数相比,NDI最高五分位数的RR为发病率2.08和死亡率2.04.
- 随着NDI的增加,观察到明显的LC风险增加趋势 (P趋势<0.01无论是发病率还是死亡率).
结论:
- 邻里贫困是肺癌发病率和死亡率的重要风险因素.
- 高NDI社区需要针对性干预,以预防LC和早期检测.
- 解决社区贫困问题可以帮助减少肺癌健康差异.
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