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超口腔激光微手术用于supraglottic癌症:前性多中心试验 (SUPRATOL) 的结果

Petra Ambrosch¹, Sylvia Meuret², Andreas Dietz³

¹Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Schleswig-Holstein (UKSH), University of Kiel, Kiel, Germany.

Frontiers in oncology

|October 7, 2024

概括

超喉喉切除术 (TLM-SGL) 的横腔激光微手术显示了高率的无吸附吞. 虽然注意到最初的发病率,但功能恢复和瘤结果在两年后是有利的.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
头部和部手术头部和部手术
在瘤学瘤学.

背景情况:

有限的数据存在于吞功能和生活质量后跨口激光微手术的supraglottic喉切除术 (TLM-SGL).
之前的回顾性研究表明,TLM-SGL的瘤结果与开放式上喉切除术 (SGL) 相似.

研究的目的:

评估功能结果,包括吞康复和生活质量,遵循TLM-SGL.
评估接受TLM-SGL+/-辅助治疗的患者的瘤控制和生存率.

主要方法:

未来的多中心SUPRATOL试验涉及102名接受TLM-SGL的患者.
主要终点:通过纤维光学内镜吞评估 (FEES) 在12个月内无吸收吞.
二级终点包括生活质量,气管切除术/胃切除术率和瘤结局.

主要成果:

在12个月后,95.5%-98.8%的患者实现了无吸入的吞.
观察到吞和语音相关生活质量的初始恶化,恢复到基线值.
对于局部控制,无喉切除术生存率,总生存率和无疾病生存率的两年卡普兰-梅尔率分别为88%,92%,93%和82%.

结论:

在12个月后,TLM-SGL+/-辅助疗法显示了高水平的无吸附吞.
观察到包括气管切除和胃切除率在内的发病率,但基本上是暂时的.
该研究证实了在报告范围内的TLM-SGL的良好的瘤结果.

关键词:

收费费用收费费用收费费用这就是为什么MDDDDDDD 这就是VHI VHI VHI.功能性结果的结果.未来的多中心试验.这种癌症叫做"supraglottic carcinoma".跨口激光微手术跨口激光微手术

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