早期卵巢缺陷妇女的阴道微生物组:一个描述性的横截面研究
Helena Patricia Giraldo1, Paulo César Giraldo2, Ticiana A Mira2
1Department of Obstetrics and Gynecology, School of Medical Sciences of Jundiaí, Jundiaí, São Paulo, Brazil.
Climacteric : the journal of the International Menopause Society
|October 7, 2024
概括
接受激素治疗 (HT) 的过早卵巢缺陷 (POI) 的女性表现出由乳球菌主导的阴道微生物组. 鉴定到的关键物种包括 Lactobacillus crispatus 和 Lactobacillus iners,这表明阴道菌群的组成一般是健康的.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 微生物组研究 微生物组研究
- 妇科 妇科 妇科 妇科
背景情况:
- 过早卵巢衰竭 (POI) 影响生育年龄的女性,往往需要激素治疗 (HT).
- 阴道微生物组在生殖健康中起着至关重要的作用,并受到荷尔蒙状况的影响.
研究的目的:
- 在被诊断为POI的女性中,以表征阴道微生物组的组成.
- 调查全身激素治疗 (HT) 对这些女性阴道菌群的影响.
主要方法:
- 一项描述性的横截面研究,涉及40名性活跃女性,在HT上至少有六个月的POI.
- 阴道分泌物使用16S rRNA基因热序测试来分析,以确定细菌群落.
- 微生物群落被分为原始基因组 (拉维尔组I-V).
主要成果:
- 研究人口的平均年龄为37.13岁,POI的平均年龄为27.90岁.
- 大多数女性 (33.4%) 呈现了拉维尔I组菌群,其特点是乳杆菌crispatus.
- 其他观察到的植物包括乳杆菌内体 (33.4%),厌氧细菌 (15.2%),乳杆菌气体 (9%) 和乳杆菌jensenii (9%).
结论:
- 经历全身性HT的POI女性显示阴道微生物组主要由乳球菌组成.
- 乳杆菌crispatus和乳杆菌iners是最常见的物种,这表明尽管POI和HT,阴道生态系统仍然存在.
- 16S rRNA热序测定提供了对在荷尔蒙治疗中POI的女性阴道微生物景观的详细见解.
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