儿童喘和过敏的发展轨迹基于父母报告和登记数据的结合
Daniil Lisik1, Göran Wennergren2, Hannu Kankaanranta1,3,4
1Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
概括
这项研究通过结合家长报告和药物数据,确定了喘,过敏性鼻炎和湿疹的九个不同的童年轨迹. 这些轨迹显示出不同的疾病发展和处方模式,表明不同的健康负担.
科学领域:
- 儿科过敏和免疫学
- 纵向队列研究 纵向队列研究
- 在健康研究中的数据整合.
背景情况:
- 儿童喘和过敏轨迹是复杂的,通常通过父母的报告或临床记录进行评估.
- 这项研究旨在通过整合家长报告的数据与客观的药物发行记录来增强轨迹的表征.
研究的目的:
- 描述儿童喘,过敏性鼻炎和湿疹同时存在的纵向轨迹.
- 探索将家长报告与分发的药物数据相结合的实用性,以进行轨迹分析.
主要方法:
- 利用基于瑞典人口的出生队列 (N=5654) 与纵向调查数据 (年龄1-12岁).
- 将调查数据与发行药物登记册数据 (2-13岁) 联系起来.
- 采用隐性类分析来识别不同的疾病轨迹,以统计和临床可解释性为指导.
主要成果:
- 确定了九个不同的轨迹,包括喘占主导地位 (复发,晚发,持续),湿疹占主导地位 (持续,缓解),过敏性鼻炎占主导地位 (晚发),多病症和低疾病负担群体.
- 观察到父母疾病报告和药物使用 (类型和数量) 的轨迹之间存在显著差异.
- 大多数 (72.2%) 的病情负担较低,而特定的多重病态发展轨迹涉及持续性湿疹和晚发过敏性鼻炎.
结论:
- 结合家长报告和分发的药物数据,可以更丰富地描述儿童喘和过敏轨迹.
- 确定的轨迹表现出疾病发展和处方的不同模式,表明不同的临床发病率负担.
- 这种综合方法将主观的患者体验与客观的医疗保健利用相结合,以更好地了解过敏性疾病的进展.
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