休息时的coeruleus部位联合激活模式在患有分离性的患者中显示出更高的状态持久性:试点研究
Samantha Weber1,2,3, Johannes Jungilligens4, Selma Aybek1,5
1Department of Neurology, Psychosomatic Medicine Unit, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
Epilepsia open
|October 7, 2024
概括
患有分离性发作的患者表现出大脑网络动态的改变,其中心脏部位 (LC) 系统在特定的大脑状态中表现出更高的持久性. 这表明受损的网络切换可能是兴奋期间解离的基础.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 分离性发作涉及在情感兴奋期间意识和控制的中断.
- (locus coeruleus) (LC) 的诺亚上腺系统与压力和兴奋有关,这表明它在解离中起着关键作用.
研究的目的:
- 调查休息时LC激活是否与分裂性发作患者的大脑网络动态变化有关.
- 为了探索患者和健康对照者之间大脑状态过渡的差异.
主要方法:
- 同激活模式 (CAP) 分析静止状态fMRI使用LC作为种子区域在14名患者和14名对照中.
- 计算已识别的CAP的进入率,持续时间和状态过渡概率.
- 使用红色核作为种子区域进行控制分析,并对诸如抑郁和焦虑等混因素进行调整.
主要成果:
- 确定了三个与LC相关的CAP,其中两个显示了默认模式和注意网络的反向激活.
- 与对照组相比,患有分离性的患者在两个LC-CAP (CAP2LC和CAP3LC) 中表现出明显更高的状态持久性.
- 用红核进行的对照分析没有揭示状态过渡概率在组间有显著差异.
结论:
- 这些发现表明,在患有分离性的患者中,LC依赖性大脑网络的高度状态持久性可能代表了分离的基础的神经机制.
- 网络切换中与兴奋相关的障碍被假设为这些患者解离的候选机制.
关键词:
同激活模式的共同激活模式在PNES中,PNES是PNES,PNES是PNES.转化障碍是一种转化障碍.连接器连接器的连接器动态功能连接的功能连接.功能性/离散性发作这里是locus coeruleus的地方.造成精神病的非发作.更多相关视频
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