相关实验视频

Updated: Jun 14, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

图形理论网络分析揭示了经典ALS患者的大脑中广泛的白质损伤

Venkateswaran Rajagopalan¹, Erik P Pioro^2,3,4

¹Department of Electrical and Electronics Engineering, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Hyderabad, India.

Amyotrophic lateral sclerosis & frontotemporal degeneration

|October 7, 2024

概括

经典的肌缩侧面硬化症 (ALS-Cl) 显示白质 (WM) 网络异常,而不是灰质 (GM) 变化,这表明神经退行可能在这种常见的ALS亚型中以轴心病开始.

科学领域:

神经成像是一种神经成像.
神经学神经学
网络科学网络科学

背景情况:

肌缩侧面硬化症 (ALS) 呈现出多种现象,其中经典ALS (ALS-Cl) 是最常见的.
磁共振成像 (MRI) 是一种非侵入性工具,用于评估ALS中中枢神经系统损伤.
之前的研究并没有专门分析ALS-Cl亚组中全脑灰质 (GM) 和白质 (WM) 网络.

研究的目的:

在使用MRI的经典ALS (ALS-Cl) 患者中调查全脑GM和WM网络变化.
为了比较ALS-Cl患者和健康的神经学对照之间的网络指标.

主要方法:

使用图形理论的灰色物质 (GM) 基于voxel的形态测量和白色物质 (WM) 网络分析应用于MRI数据.
该研究包括25名ALS-Cl患者和14名神经学对照.

主要成果:

在ALS-Cl患者和对照人群之间没有发现转基因的显著差异.
WM网络分析显示,ALS-Cl患者的外运动区域网络程度发生了显著的变化.
全球和局部图表指标显示,与对照组相比,ALS-Cl患者的显著异常.

结论:

在ALS-Cl中没有转基因变化的显著WM变化表明,神经退行可能最初表现为这种亚型中的"轴心病".
这项研究强调了网络分析在识别ALS-Cl.中微妙的神经退行变化的有用性.

关键词:

经典的ALS是一种经典的ALS.在 DTI 中,DTI 是 DTI.图形网络分析图形网络分析白质是白色物质的组成部分.

更多相关视频

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

相关概念视频

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...

Alzheimer Disease l: Introduction

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

Alzheimer Disease ll: Pathophysiology

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

Dementia l: Introduction

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...